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Fam3c Gene Detail
Summary
  • Symbol
    Fam3c
  • Name
    FAM3 metabolism regulating signaling molecule C
  • Synonyms
    D6Wsu176e, Fam3c, Ilei
  • Feature Type
    protein coding gene
  • IDs
    MGI:107892
    NCBI Gene: 27999
  • Alliance
  • Transcription Start Sites
    10 TSS
  • Candidate for QTL
    7 QTL
Location &
Maps
more
  • Sequence Map
    Chr6:22306519-22356080 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 9.24 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1831 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107892
protein coding gene Chr6:22306519-22356242 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030484
protein coding gene Chr6:19809674-19860397 (-)
A/J MGP_AJ_G0030457
protein coding gene Chr6:18990426-19040095 (-)
AKR/J MGP_AKRJ_G0030384
protein coding gene Chr6:19595022-19644624 (-)
BALB/cJ MGP_BALBcJ_G0030466
protein coding gene Chr6:19069648-19119989 (-)
C3H/HeJ MGP_C3HHeJ_G0030180
protein coding gene Chr6:19544032-19593314 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030921
protein coding gene Chr6:20404691-20456196 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028132
protein coding gene Chr6:17591429-17643425 (-)
CAST/EiJ MGP_CASTEiJ_G0029582
protein coding gene Chr6:19486293-19536224 (-)
CBA/J MGP_CBAJ_G0030158
protein coding gene Chr6:21086593-21139689 (-)
DBA/2J MGP_DBA2J_G0030302
protein coding gene Chr6:18894121-18943777 (-)
FVB/NJ MGP_FVBNJ_G0030256
protein coding gene Chr6:18692287-18740599 (-)
LP/J MGP_LPJ_G0030389
protein coding gene Chr6:19922314-19971818 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030292
protein coding gene Chr6:22914413-22965731 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030951
protein coding gene Chr6:19553768-19605871 (-)
PWK/PhJ MGP_PWKPhJ_G0029296
protein coding gene Chr6:18573404-18623785 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029132
protein coding gene Chr6:19291334-19341994 (-)
WSB/EiJ MGP_WSBEiJ_G0029658
protein coding gene Chr6:19441558-19492433 (-)



Homology
more
  • Human Ortholog
    FAM3C, FAM3 metabolism regulating signaling molecule C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FAM3C, FAM3 metabolism regulating signaling molecule C
  • Synonyms
    GS3786, ILEI
  • Links
    NCBI Gene ID: 10447
    neXtProt AC: NX_Q92520
    UniProt: Q92520

  • Chr Location
    7q31.31; chr7:121348878-121396396 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 1 genetic background
    1 phenotype from multigenic genotypes
    11 phenotype references
Mice homozygous for a knock-out or gene trap allele exhibit normal skeletal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 27999 NCBI Gene Model | MGI Sequence Detail 49562 C57BL/6J ±  kb
transcript NM_138587 RefSeq | MGI Sequence Detail 2739 ZRU/MplStud  
polypeptide Q91VU0 UniProt | EBI | MGI Sequence Detail 227 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 12
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-36470
References
more
  • Summaries
    All 48
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
  • Latest
    J:340692 Schmidt U, et al., Inducible overexpression of a FAM3C/ILEI transgene has pleiotropic effects with shortened life span, liver fibrosis and anemia in mice. PLoS One. 2023;18(9):e0286256

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory