Dennd2d MGI Mouse Gene Detail - MGI:2181193

Symbol

Dennd2d
Name

DENN domain containing 2D
Synonyms

2010308M01Rik, MGC:6915

Feature Type

protein coding gene
IDs

MGI:2181193
NCBI Gene: 72121
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr3:106389745-106410346 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 46.49 cM
Mapping Data

2 experiments

SNPs within 2kb

472 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2181193	protein coding gene	Chr3:106389721-106410346 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027733	protein coding gene	Chr3:107948479-107969067 (+)
A/J	MGP_AJ_G0027693	protein coding gene	Chr3:104518112-104538824 (+)
AKR/J	MGP_AKRJ_G0027658	protein coding gene	Chr3:107073303-107094173 (+)
BALB/cJ	MGP_BALBcJ_G0027705	protein coding gene	Chr3:104215861-104236908 (+)
C3H/HeJ	MGP_C3HHeJ_G0027435	protein coding gene	Chr3:107403650-107425220 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028149	protein coding gene	Chr3:111966749-111992004 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025487	protein coding gene	Chr3:100699778-100720410 (+)
CAST/EiJ	MGP_CASTEiJ_G0026891	protein coding gene	Chr3:106780600-106801046 (+)
CBA/J	MGP_CBAJ_G0027410	protein coding gene	Chr3:115760625-115782998 (+)
DBA/2J	MGP_DBA2J_G0027552	protein coding gene	Chr3:103723912-103745174 (+)
FVB/NJ	MGP_FVBNJ_G0027520	protein coding gene	Chr3:101633016-101654237 (+)
LP/J	MGP_LPJ_G0027659	protein coding gene	Chr3:109323177-109345585 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027550	protein coding gene	Chr3:121837112-121858855 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028204	protein coding gene	Chr3:106634438-106655061 (+)
PWK/PhJ	MGP_PWKPhJ_G0026617	protein coding gene	Chr3:103456158-103476899 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026437	protein coding gene	Chr3:104762648-104783279 (+)
WSB/EiJ	MGP_WSBEiJ_G0026971	protein coding gene	Chr3:107201804-107222356 (+)

Human Ortholog

DENND2D, DENN domain containing 2D

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DENND2D, DENN domain containing 2D
Links

HGNC:26192

NCBI Gene ID: 79961

neXtProt AC: NX_Q9H6A0

UniProt: Q9H6A0
Chr Location

1p13.3-p13.2; chr1:111185969-111204578 (-) GRCh38

MGI Vertebrate Homology

Dennd2d stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: DENND2D
Gene Tree

Dennd2d

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Dennd2d
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

23 strains or lines available

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

747
Tissues

41
cDNA Data

9
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dennd2d

ZFIN dennd2db

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All Sequences

52
RefSeq

10
UniProt

3
CCDS

CCDS17722.2, CCDS51040.1

Ensembl

ENSMUSG00000027901 (Evidence)
NCBI Gene

72121

			Length	Strain/Species	Flank
genomic	72121	NCBI Gene Model \| MGI Sequence Detail	20602	C57BL/6J	± kb
transcript	NM_001278941	RefSeq \| MGI Sequence Detail	4129	C57BL/6
polypeptide	Q91VV4	UniProt \| EBI \| MGI Sequence Detail	469	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000032767 DENN domain-containing protein 2D

(term hierarchy)
InterPro Domains

IPR001194 cDENN domain

IPR005112 dDENN domain

IPR051942 DENN domain-containing protein 2

IPR043153 DENN domain, C-terminal lobe

IPR037516 Tripartite DENN domain

IPR005113 uDENN domain

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All nucleic 9

cDNA 9

Microarray probesets 3

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MGI:1919371, MGI:2139721

Summaries

All 32

Developmental Gene Expression 1

Diseases 1

Gene Ontology 4

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dennd2d:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31109	Chr3:106389743-106389793 (+)	23 bp
Tssr31110	Chr3:106389873-106389887 (+)	135 bp
Tssr31111	Chr3:106389923-106389976 (+)	205 bp
Tssr31112	Chr3:106393325-106393373 (+)	3,604 bp
Tssr31113	Chr3:106393375-106393408 (+)	3,647 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24