Sh3bgrl3 MGI Mouse Gene Detail - MGI:1920973 - SH3 domain binding glutamic acid-rich protein-like 3

Symbol

Sh3bgrl3
Name

SH3 domain binding glutamic acid-rich protein-like 3
Synonyms

1110004L05Rik

Feature Type

protein coding gene
IDs

MGI:1920973
NCBI Gene: 73723
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr4:133854717-133856044 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 66.50 cM
Mapping Data

2 experiments

SNPs within 2kb

103 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920973	protein coding gene	Chr4:133854717-133856100 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028913	protein coding gene	Chr4:136461776-136463159 (-)
A/J	MGP_AJ_G0028872	protein coding gene	Chr4:130715289-130716672 (-)
AKR/J	MGP_AKRJ_G0028824	protein coding gene	Chr4:134465420-134466803 (-)
BALB/cJ	MGP_BALBcJ_G0028895	protein coding gene	Chr4:131365520-131366903 (-)
C3H/HeJ	MGP_C3HHeJ_G0028609	protein coding gene	Chr4:134702382-134703765 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029337	protein coding gene	Chr4:141367780-141369163 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026608	protein coding gene	Chr4:123781757-123783115 (-)
CAST/EiJ	MGP_CASTEiJ_G0028042	protein coding gene	Chr4:132821928-132823312 (-)
CBA/J	MGP_CBAJ_G0028574	protein coding gene	Chr4:145088466-145089849 (-)
DBA/2J	MGP_DBA2J_G0028723	protein coding gene	Chr4:131148502-131149885 (-)
FVB/NJ	MGP_FVBNJ_G0028691	protein coding gene	Chr4:130040969-130042352 (-)
LP/J	MGP_LPJ_G0028824	protein coding gene	Chr4:136545702-136547085 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028716	protein coding gene	Chr4:149582851-149584234 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029375	protein coding gene	Chr4:134886043-134887426 (-)
PWK/PhJ	MGP_PWKPhJ_G0027762	protein coding gene	Chr4:127875061-127876444 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027588	protein coding gene	Chr4:130731469-130732846 (-)
WSB/EiJ	MGP_WSBEiJ_G0028121	protein coding gene	Chr4:135074626-135076009 (-)

Human Ortholog

SH3BGRL3, SH3 domain binding glutamate rich protein like 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SH3BGRL3, SH3 domain binding glutamate rich protein like 3
Synonyms

HEL-S-297, SH3BP-1, TIP-B1
Links

HGNC:15568

NCBI Gene ID: 83442

neXtProt AC: NX_Q9H299

UniProt: Q9H299
Chr Location

1p36.11; chr1:26280086-26281522 (+) GRCh38

MGI Vertebrate Homology

Sh3bgrl3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SH3BGRL3
Gene Tree

Sh3bgrl3

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

2
Gene trapped

4
Radiation induced

1
Targeted

5
Genomic Mutations

4 involving Sh3bgrl3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

13 strains or lines available

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

765
Tissues

9
cDNA Data

7
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SH3BGRL3

Xenbase sh3bgrl3

ZFIN sh3bgrl3

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All Sequences

37
RefSeq

2
UniProt

2
CCDS

CCDS38910.1

Ensembl

ENSMUSG00000028843 (Evidence)
NCBI Gene

73723

			Length	Strain/Species	Flank
genomic	73723	NCBI Gene Model \| MGI Sequence Detail	1328	C57BL/6J	± kb
transcript	NM_080559	RefSeq \| MGI Sequence Detail	687	C57BL/6
polypeptide	Q91VW3	UniProt \| EBI \| MGI Sequence Detail	93	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014817 SH3 domain-binding glutamic acid-rich-like protein 3

(term hierarchy)
PDB

1J0F, 1T1V
InterPro Domains

IPR006993 SH3-binding, glutamic acid-rich protein

IPR051033 SH3 domain-binding glutamic acid-rich protein

IPR036249 Thioredoxin-like superfamily
GlyGen

Q91VW3 2 sites, 1 O-linked glycan (1 site)

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All nucleic 7

cDNA 7

Microarray probesets 3

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MGI:2140464

Summaries

All 41

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 14
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sh3bgrl3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr43877	Chr4:133856915-133856922 (-)	-875 bp
Tssr43876	Chr4:133856018-133856081 (-)	-6 bp
Tssr43875	Chr4:133855991-133856011 (-)	43 bp
Tssr43874	Chr4:133855393-133855402 (-)	646 bp
Tssr43873	Chr4:133855363-133855387 (-)	669 bp
Tssr43872	Chr4:133855340-133855361 (-)	693 bp
Tssr43871	Chr4:133855310-133855334 (-)	722 bp
Tssr43870	Chr4:133855262-133855284 (-)	771 bp
Tssr43869	Chr4:133855109-133855122 (-)	928 bp
Tssr43868	Chr4:133855034-133855102 (-)	976 bp
Tssr43867	Chr4:133854998-133855031 (-)	1,029 bp
Tssr43866	Chr4:133854938-133854997 (-)	1,076 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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