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Cytip Gene Detail
Summary
  • Symbol
    Cytip
  • Name
    cytohesin 1 interacting protein
  • Synonyms
    A130053M09Rik, Cbp, Cybr, Pscdbp
  • Feature Type
    protein coding gene
  • IDs
    MGI:2183535
    NCBI Gene: 227929
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:58019149-58085544 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 33.05 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1980 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2183535
 protein coding gene Chr2:58019149-58085559 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025747
 protein coding gene Chr2:57666282-57739237 (-)
A/J MGP_AJ_G0025723
 protein coding gene Chr2:55456660-55520134 (-)
AKR/J MGP_AKRJ_G0025693
 protein coding gene Chr2:56988793-57053750 (-)
BALB/cJ MGP_BALBcJ_G0025718
 protein coding gene Chr2:55550999-55621618 (-)
C3H/HeJ MGP_C3HHeJ_G0025479
 protein coding gene Chr2:57064099-57131129 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026165
 protein coding gene Chr2:59404808-59475285 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023570
 protein coding gene Chr2:53047959-53113542 (-)
CAST/EiJ MGP_CASTEiJ_G0024944
 protein coding gene Chr2:57071097-57147461 (-)
CBA/J MGP_CBAJ_G0025459
 protein coding gene Chr2:61612807-61690870 (-)
DBA/2J MGP_DBA2J_G0025590
 protein coding gene Chr2:55072691-55138038 (-)
FVB/NJ MGP_FVBNJ_G0025552
 protein coding gene Chr2:54604865-54669671 (-)
LP/J MGP_LPJ_G0025678
 protein coding gene Chr2:57528789-57600253 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025583
 protein coding gene Chr2:63332740-63401734 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026222
 protein coding gene Chr2:56963147-57038722 (-)
PWK/PhJ MGP_PWKPhJ_G0024685
 protein coding gene Chr2:54892718-54964540 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024491
 protein coding gene Chr2:57074518-57148266 (-)
WSB/EiJ MGP_WSBEiJ_G0025011
 protein coding gene Chr2:57265308-57336606 (-)



Homology
more
  • Human Ortholog
    CYTIP, cytohesin 1 interacting protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYTIP, cytohesin 1 interacting protein
  • Synonyms
    B3-1, CASP, CYBR, CYTHIP, HE, PSCDBP
  • Links
    NCBI Gene ID: 9595
    neXtProt AC: NX_O60759
    UniProt: O60759

  • Chr Location
    2q24.1; chr2:157409360-157491093 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display impaired trafficking and/or cell adhesion of immune system cells. Mice homozygous for a reporter allele show normal immune cell development and function; however, mutant hematopoietic stems cells have impaired repopulating activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    20
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026832 Ensembl Gene Model | MGI Sequence Detail 66396 C57BL/6J ±  kb
    transcript ENSMUST00000028175 Ensembl | MGI Sequence Detail 6110 Not Applicable  
    polypeptide ENSMUSP00000028175 Ensembl | MGI Sequence Detail 359 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 23
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2138967, MGI:2139510, MGI:2444809
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory