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Adcy4 Gene Detail
Summary
  • Symbol
    Adcy4
  • Name
    adenylate cyclase 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:99674
    NCBI Gene: 104110
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:56006514-56021552 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 28.19 cM, cytoband D3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    330 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99674
 protein coding gene Chr14:56006513-56021552 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021371
 protein coding gene Chr14:49812854-49830046 (-)
A/J MGP_AJ_G0021330
 protein coding gene Chr14:48827133-48842255 (-)
AKR/J MGP_AKRJ_G0021306
 protein coding gene Chr14:50574609-50589593 (-)
BALB/cJ MGP_BALBcJ_G0021334
 protein coding gene Chr14:48791630-48806783 (-)
C3H/HeJ MGP_C3HHeJ_G0021114
 protein coding gene Chr14:50263596-50278576 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021772
 protein coding gene Chr14:52308766-52323796 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019319
 protein coding gene Chr14:47191542-47207011 (-)
CAST/EiJ MGP_CASTEiJ_G0020633
 protein coding gene Chr14:46522294-46542473 (-)
CBA/J MGP_CBAJ_G0021081
 protein coding gene Chr14:53876409-53892830 (-)
DBA/2J MGP_DBA2J_G0021202
 protein coding gene Chr14:48542405-48557809 (-)
FVB/NJ MGP_FVBNJ_G0021184
 protein coding gene Chr14:47990927-48006194 (-)
LP/J MGP_LPJ_G0021276
 protein coding gene Chr14:50863568-50879467 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021208
 protein coding gene Chr14:53234860-53249832 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021799
 protein coding gene Chr14:49755653-49772495 (-)
PWK/PhJ MGP_PWKPhJ_G0020380
 protein coding gene Chr14:45076376-45091628 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020208
 protein coding gene Chr14:45761365-45776609 (-)
WSB/EiJ MGP_WSBEiJ_G0020686
 protein coding gene Chr14:50040009-50056741 (-)



Homology
more
  • Human Ortholog
    ADCY4, adenylate cyclase 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADCY4, adenylate cyclase 4
  • Synonyms
    AC4
  • Links
    NCBI Gene ID: 196883
    neXtProt AC: NX_Q8NFM4
    UniProt: Q8NFM4

  • Chr Location
    14q12; chr14:24318349-24335093 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Mice homozygous for disruptions of this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1037
  • Tissues
    235
  • cDNA Data
    17
  • Literature Summary
    11
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022220 Ensembl Gene Model | MGI Sequence Detail 15039 C57BL/6J ±  kb
transcript ENSMUST00000170223 Ensembl | MGI Sequence Detail 3501 Not Applicable  
polypeptide ENSMUSP00000130530 Ensembl | MGI Sequence Detail 1077 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 19
    Primer pair 2
    Other 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-16459
References
more
  • Summaries
    All 42
    Developmental Gene Expression 11
    Gene Ontology 9
    Phenotypes 7
  • Earliest
    J:46601 Gao BN, et al., Cloning and expression of a widely distributed (type IV) adenylyl cyclase. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10178-82
  • Latest
    J:350533 Li G, et al., Coexistence within one cell of microvillous and ciliary phototransductions across M1- through M6-IpRGCs. Proc Natl Acad Sci U S A. 2023 Dec 26;120(52):e2315282120
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory