Insig2 MGI Mouse Gene Detail - MGI:1920249

Symbol

Insig2
Name

insulin induced gene 2
Synonyms

2900053I11Rik, C730043J18Rik, Insig-2

Feature Type

protein coding gene
IDs

MGI:1920249
NCBI Gene: 72999
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr1:121232082-121260318 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 52.91 cM, cytoband E2
Mapping Data

3 experiments

SNPs within 2kb

862 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920249	protein coding gene	Chr1:121232082-121260391 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016409	protein coding gene	Chr1:124122320-124151932 (-)
A/J	MGP_AJ_G0016392	protein coding gene	Chr1:119670975-119699185 (-)
AKR/J	MGP_AKRJ_G0016357	protein coding gene	Chr1:123178013-123206214 (-)
BALB/cJ	MGP_BALBcJ_G0016352	protein coding gene	Chr1:119948895-119978108 (-)
C3H/HeJ	MGP_C3HHeJ_G0016178	protein coding gene	Chr1:123353400-123381708 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016813	protein coding gene	Chr1:128863017-128893174 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014526	protein coding gene	Chr1:113305140-113334272 (-)
CAST/EiJ	MGP_CASTEiJ_G0015759	protein coding gene	Chr1:122176143-122203874 (-)
CBA/J	MGP_CBAJ_G0016151	protein coding gene	Chr1:133302163-133334570 (-)
DBA/2J	MGP_DBA2J_G0016257	protein coding gene	Chr1:118693583-118723741 (-)
FVB/NJ	MGP_FVBNJ_G0016256	protein coding gene	Chr1:117458202-117485007 (-)
LP/J	MGP_LPJ_G0016328	protein coding gene	Chr1:125478425-125508593 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016281	protein coding gene	Chr1:139006896-139036473 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016849	protein coding gene	Chr1:122935300-122964511 (-)
PWK/PhJ	MGP_PWKPhJ_G0015545	protein coding gene	Chr1:117701693-117730346 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015333	protein coding gene	Chr1:121848898-121875735 (-)
WSB/EiJ	MGP_WSBEiJ_G0015821	protein coding gene	Chr1:122810831-122841809 (-)

Human Ortholog

INSIG2, insulin induced gene 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

INSIG2, insulin induced gene 2
Synonyms

INSIG-2
Links

HGNC:20452

NCBI Gene ID: 51141

neXtProt AC: NX_Q9Y5U4

UniProt: Q9Y5U4
Chr Location

2q14.1-q14.2; chr2:118088452-118110997 (+) GRCh38

MGI Vertebrate Homology

Insig2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: INSIG2
Gene Tree

Insig2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
11 phenotypes from multigenic genotypes
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

2
Endonuclease-mediated

3
Radiation induced

1
Targeted

2
Genomic Mutations

3 involving Insig2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

34
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

770
Tissues

32
cDNA Data

15
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase insig2

ZFIN insig2

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All Sequences

109
RefSeq

28
UniProt

8
CCDS

CCDS15236.1, CCDS78670.1

Ensembl

ENSMUSG00000003721 (Evidence)
NCBI Gene

72999

			Length	Strain/Species	Flank
genomic	ENSMUSG00000003721	Ensembl Gene Model \| MGI Sequence Detail	28237	C57BL/6J	± kb
transcript	ENSMUST00000003818	Ensembl \| MGI Sequence Detail	2697	Not Applicable
polypeptide	ENSMUSP00000003818	Ensembl \| MGI Sequence Detail	225	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000009057 insulin-induced gene 2 protein

(term hierarchy)
InterPro Domains

IPR025929 Insulin-induced protein family

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All nucleic 15

cDNA 15

Microarray probesets 5

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MGI:2443230

Summaries

All 54

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 18
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Insig2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr13287	Chr1:121260391-121260400 (-)	-78 bp
Tssr13286	Chr1:121260300-121260316 (-)	10 bp
Tssr13285	Chr1:121260274-121260297 (-)	32 bp
Tssr13284	Chr1:121260244-121260267 (-)	62 bp
Tssr13283	Chr1:121255756-121255773 (-)	4,553 bp
Tssr13282	Chr1:121255505-121255532 (-)	4,799 bp
Tssr13281	Chr1:121255463-121255497 (-)	4,838 bp
Tssr13280	Chr1:121255401-121255419 (-)	4,908 bp
Tssr13279	Chr1:121255380-121255386 (-)	4,935 bp
Tssr13278	Chr1:121235676-121235702 (-)	24,629 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24