Baat MGI Mouse Gene Detail - MGI:106642 - bile acid-Coenzyme A: amino acid N-acyltransferase

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Baat Gene Detail

Symbol

Baat
Name

bile acid-Coenzyme A: amino acid N-acyltransferase
Synonyms

BAT, taurine N-acyltransferase

Feature Type

protein coding gene
IDs

MGI:106642
NCBI Gene: 12012
Alliance

gene page
Transcription Start Sites

3 TSS
Candidate for QTL

5 QTL

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Sequence Map

Chr4:49489422-49506557 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 26.51 cM
Mapping Data

7 experiments

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SNPs within 2kb

514 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_106642	protein coding gene	Chr4:49489416-49507915 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028281	protein coding gene	Chr4:47972266-47987524 (-)
A/J	MGP_AJ_G0028241	protein coding gene	Chr4:46193951-46209519 (-)
AKR/J	MGP_AKRJ_G0028190	protein coding gene	Chr4:47407399-47423445 (-)
BALB/cJ	MGP_BALBcJ_G0028260	protein coding gene	Chr4:46301979-46318223 (-)
C3H/HeJ	MGP_C3HHeJ_G0027981	protein coding gene	Chr4:47960725-47977798 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028701	protein coding gene	Chr4:49699694-49715594 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026010	protein coding gene	Chr4:43397101-43415050 (-)
CAST/EiJ	MGP_CASTEiJ_G0027420	protein coding gene	Chr4:47533762-47549884 (-)
CBA/J	MGP_CBAJ_G0027947	protein coding gene	Chr4:51384560-51426594 (-)
DBA/2J	MGP_DBA2J_G0028097	protein coding gene	Chr4:46079030-46094890 (-)
FVB/NJ	MGP_FVBNJ_G0028064	protein coding gene	Chr4:45340285-45356450 (-)
LP/J	MGP_LPJ_G0028196	protein coding gene	Chr4:48052206-48065797 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028088	protein coding gene	Chr4:54309353-54330134 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028736	protein coding gene	Chr4:47598329-47619262 (-)
PWK/PhJ	MGP_PWKPhJ_G0027145	protein coding gene	Chr4:46139072-46170405 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026973	protein coding gene	Chr4:46995039-47011086 (-)
WSB/EiJ	MGP_WSBEiJ_G0027498	protein coding gene	Chr4:47503661-47520693 (-)

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Human Ortholog

BAAT, bile acid-CoA:amino acid N-acyltransferase

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BAAT, bile acid-CoA:amino acid N-acyltransferase
Synonyms

BACAT, BACD1, BAT, HCHO
Links

HGNC:932

NCBI Gene ID: 570

neXtProt AC: NX_Q14032

UniProt: Q14032
Chr Location

9q31.1; chr9:101354182-101385400 (-) GRCh38

MGI Vertebrate Homology

Baat stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: BAAT
Protein SuperFamily

Acyl-CoA_hydro
Gene Tree

Baat

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Diseases

1 with human BAAT associations

				Human Disease	Mouse Models
				disease of metabolism IDs disease of metabolism DOID:0014667 ICD10CM:E88.9 ICD9CM:277.9 MESH:D008659 NCI:C3235 UMLS_CUI:C0025517

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

3
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

42
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

20
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase baat

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All Sequences

38
RefSeq

4
UniProt

1
CCDS

CCDS18173.1

Ensembl

ENSMUSG00000039653 (Evidence)
NCBI Gene

12012

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000039653	Ensembl Gene Model \| MGI Sequence Detail	17136	C57BL/6J	± kb
	transcript	ENSMUST00000166036	Ensembl \| MGI Sequence Detail	1263	Not Applicable
	polypeptide	ENSMUSP00000129603	Ensembl \| MGI Sequence Detail	420	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000004614 bile acid-CoA:amino acid N-acyltransferase

(term hierarchy)
EC

2.3.1.65, 3.1.2.2, 3.1.2.27
InterPro Domains

IPR016662 Acyl-CoA thioesterase, long chain

IPR042490 Acyl-CoA thioester hydrolase/BAAT, N-terminal

IPR006862 Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase

IPR029058 Alpha/Beta hydrolase fold

IPR014940 BAAT/Acyl-CoA thioester hydrolase C-terminal
GlyGen

Q91X34 1 site, 1 O-linked glycan (1 site)

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All nucleic 20

cDNA 20

Microarray probesets 4

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MGD-MRK-35099, MGI:2140193, MGI:2140199

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Summaries

All 44

Developmental Gene Expression 1

Gene Ontology 11

Phenotypes 8
Earliest

J:36805 Nuglozeh E, et al., Genetic mapping of the C-type natriuretic peptide receptor (Npr2) gene to mouse chromosome 4. Mamm Genome. 1997 Aug;8(8):624-5
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Baat:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr41662	Chr4:49506538-49506563 (-)	6 bp
Tssr41661	Chr4:49506528-49506533 (-)	26 bp
Tssr41660	Chr4:49506490-49506513 (-)	55 bp

Baat is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Bglq4	Chr4, 33.96 cM		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Tafat (80 cM) on mouse Chromosome 4 as identified by ExQuest are Ela2, Ela3b, and Dvl1 (82 cM). Chr 10 locus Ela2 exhibits 55-fold decreased expression in the pancreas of Tally Ho animals compared to C57BL/6J. For QTL Bwq1 (6.3 cM), potential candidate gene Decr1 was identified. For QTLs Triglq1 (6.5 cM) and Bglq4 (6.5 cM), potential candidate genes Ttpa, Bhmt(Chr 13), Baat(22.7 cM), and Aldob (22.3 cM) were identified. For QTLs Nidd1 (48 cM) and Dob1 (50 cM), potential candidate genes Lepr (46.7 cM), Dio1 (48.7 cM), Scp2 (52 cM), Faah (56.5 cM), and Usp1 were identified.
Dob1	Chr4, syntenic	Chr4:101574601-123127211	J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Tafat (80 cM) on mouse Chromosome 4 as identified by ExQuest are Ela2, Ela3b, and Dvl1 (82 cM). Chr 10 locus Ela2 exhibits 55-fold decreased expression in the pancreas of Tally Ho animals compared to C57BL/6J. For QTL Bwq1 (6.3 cM), potential candidate gene Decr1 was identified. For QTLs Triglq1 (6.5 cM) and Bglq4 (6.5 cM), potential candidate genes Ttpa, Bhmt(Chr 13), Baat(22.7 cM), and Aldob (22.3 cM) were identified. For QTLs Nidd1 (48 cM) and Dob1 (50 cM), potential candidate genes Lepr (46.7 cM), Dio1 (48.7 cM), Scp2 (52 cM), Faah (56.5 cM), and Usp1 were identified.
Nidd1	Chr4, syntenic		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Tafat (80 cM) on mouse Chromosome 4 as identified by ExQuest are Ela2, Ela3b, and Dvl1 (82 cM). Chr 10 locus Ela2 exhibits 55-fold decreased expression in the pancreas of Tally Ho animals compared to C57BL/6J. For QTL Bwq1 (6.3 cM), potential candidate gene Decr1 was identified. For QTLs Triglq1 (6.5 cM) and Bglq4 (6.5 cM), potential candidate genes Ttpa, Bhmt(Chr 13), Baat(22.7 cM), and Aldob (22.3 cM) were identified. For QTLs Nidd1 (48 cM) and Dob1 (50 cM), potential candidate genes Lepr (46.7 cM), Dio1 (48.7 cM), Scp2 (52 cM), Faah (56.5 cM), and Usp1 were identified.
Tafat	Chr4, 74.75 cM	Chr4:141621281-141621387	J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Tafat (80 cM) on mouse Chromosome 4 as identified by ExQuest are Ela2, Ela3b, and Dvl1 (82 cM). Chr 10 locus Ela2 exhibits 55-fold decreased expression in the pancreas of Tally Ho animals compared to C57BL/6J. For QTL Bwq1 (6.3 cM), potential candidate gene Decr1 was identified. For QTLs Triglq1 (6.5 cM) and Bglq4 (6.5 cM), potential candidate genes Ttpa, Bhmt(Chr 13), Baat(22.7 cM), and Aldob (22.3 cM) were identified. For QTLs Nidd1 (48 cM) and Dob1 (50 cM), potential candidate genes Lepr (46.7 cM), Dio1 (48.7 cM), Scp2 (52 cM), Faah (56.5 cM), and Usp1 were identified.
Triglq1	Chr4, 10.61 cM	Chr4:25683240-25683429	J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Tafat (80 cM) on mouse Chromosome 4 as identified by ExQuest are Ela2, Ela3b, and Dvl1 (82 cM). Chr 10 locus Ela2 exhibits 55-fold decreased expression in the pancreas of Tally Ho animals compared to C57BL/6J. For QTL Bwq1 (6.3 cM), potential candidate gene Decr1 was identified. For QTLs Triglq1 (6.5 cM) and Bglq4 (6.5 cM), potential candidate genes Ttpa, Bhmt(Chr 13), Baat(22.7 cM), and Aldob (22.3 cM) were identified. For QTLs Nidd1 (48 cM) and Dob1 (50 cM), potential candidate genes Lepr (46.7 cM), Dio1 (48.7 cM), Scp2 (52 cM), Faah (56.5 cM), and Usp1 were identified.

*cM position of peak correlated region/marker

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