Ncald MGI Mouse Gene Detail - MGI:1196326

Symbol

Ncald
Name

neurocalcin delta
Synonyms

D030020D09Rik, D15Ertd412e

Feature Type

protein coding gene
IDs

MGI:1196326
NCBI Gene: 52589
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr15:37366419-37792814 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 14.94 cM
Mapping Data

4 experiments

SNPs within 2kb

12635 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1196326	protein coding gene	Chr15:37366419-37792816 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021802	protein coding gene	Chr15:35811656-36263627 (-)
A/J	MGP_AJ_G0021762	protein coding gene	Chr15:34448496-34874907 (-)
AKR/J	MGP_AKRJ_G0021742	protein coding gene	Chr15:35439402-35889929 (-)
BALB/cJ	MGP_BALBcJ_G0021769	protein coding gene	Chr15:34488619-34918986 (-)
C3H/HeJ	MGP_C3HHeJ_G0021543	protein coding gene	Chr15:35403649-35847266 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022208	protein coding gene	Chr15:37224029-37683205 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019745	protein coding gene	Chr15:32241294-32655713 (-)
CAST/EiJ	MGP_CASTEiJ_G0021060	protein coding gene	Chr15:35789886-36247544 (-)
CBA/J	MGP_CBAJ_G0021512	protein coding gene	Chr15:38397456-38901070 (-)
DBA/2J	MGP_DBA2J_G0021636	protein coding gene	Chr15:34284823-34714809 (-)
FVB/NJ	MGP_FVBNJ_G0021614	protein coding gene	Chr15:33689312-34111265 (-)
LP/J	MGP_LPJ_G0021706	protein coding gene	Chr15:35686487-36121833 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021638	protein coding gene	Chr15:41446794-41915654 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022231	protein coding gene	Chr15:35591941-36042376 (-)
PWK/PhJ	MGP_PWKPhJ_G0020804	protein coding gene	Chr15:34312158-34749173 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020642	protein coding gene	Chr15:35279494-35727073 (-)
WSB/EiJ	MGP_WSBEiJ_G0021115	protein coding gene	Chr15:35545544-35983540 (-)

Human Ortholog

NCALD, neurocalcin delta

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NCALD, neurocalcin delta
Links

HGNC:7655

NCBI Gene ID: 83988

neXtProt AC: NX_P61601

UniProt: P61601
Chr Location

8q22.3; chr8:101686542-102124907 (-) GRCh38

MGI Vertebrate Homology

Ncald stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NCALD
Gene Tree

Ncald

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Phenotype Summary

39 phenotypes from 2 alleles in 3 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

1
Targeted

3
Genomic Mutations

2 involving Ncald
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a knock-out allele show reduced fertility, decreased body and brain weight, enlarged lateral ventricles, a reduction in subgranular zone length of the dentate gyrus, impaired adult neurogenesis in the hippocampus, and increased axonal length in spinal motor neurons.

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All GO Annotations

17
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

860
Tissues

58
cDNA Data

85
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ncald

ZFIN ncaldb

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All Sequences

159
RefSeq

96
UniProt

4
CCDS

CCDS27435.1

Ensembl

ENSMUSG00000051359 (Evidence)
NCBI Gene

52589

			Length	Strain/Species	Flank
genomic	ENSMUSG00000051359	Ensembl Gene Model \| MGI Sequence Detail	426396	C57BL/6J	± kb
transcript	ENSMUST00000168992	Ensembl \| MGI Sequence Detail	3538	Not Applicable
polypeptide	ENSMUSP00000130126	Ensembl \| MGI Sequence Detail	193	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000011017 neurocalcin-delta

(term hierarchy)
InterPro Domains

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR028846 Recoverin family

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All nucleic 87

cDNA 86

Primer pair 1

Microarray probesets 5

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MGI:1925700, MGI:2146078

Summaries

All 55

Developmental Gene Expression 10

Gene Ontology 6

Phenotypes 18
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:346372 Kolesova H, et al., Reprogramming of the developing heart by Hif1a-deficient sympathetic system and maternal diabetes exposure. Front Endocrinol (Lausanne). 2024;15:1344074

TSS for Ncald:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr134105	Chr15:37792635-37792659 (-)	167 bp
Tssr134104	Chr15:37792410-37792432 (-)	393 bp
Tssr134103	Chr15:37792283-37792304 (-)	520 bp
Tssr134102	Chr15:37792263-37792280 (-)	542 bp
Tssr134101	Chr15:37792237-37792249 (-)	571 bp
Tssr134100	Chr15:37780568-37780589 (-)	12,235 bp
Tssr134090	Chr15:37381860-37381865 (-)	410,951 bp
Tssr134089	Chr15:37368559-37368570 (-)	424,249 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24