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Chia1 Gene Detail
Summary
  • Symbol
    Chia1
  • Name
    chitinase, acidic 1
  • Synonyms
    2200003E03Rik, AMCase, Chia, YNL
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932052
    NCBI Gene: 81600
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:106020698-106039434 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 46.49 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    501 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932052
 protein coding gene Chr3:106020545-106039436 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027729
 protein coding gene Chr3:107504568-107527594 (+)
A/J MGP_AJ_G0027689
 protein coding gene Chr3:104075930-104096149 (+)
AKR/J MGP_AKRJ_G0027654
 protein coding gene Chr3:106669836-106688554 (+)
BALB/cJ MGP_BALBcJ_G0027701
 protein coding gene Chr3:103850915-103868450 (+)
C3H/HeJ MGP_C3HHeJ_G0027431
 protein coding gene Chr3:107002045-107023067 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028145
 protein coding gene Chr3:111523629-111553073 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025485
 protein coding gene Chr3:100129480-100148013 (+)
CAST/EiJ MGP_CASTEiJ_G0026887
 protein coding gene Chr3:106154238-106173866 (+)
CBA/J MGP_CBAJ_G0027406
 protein coding gene Chr3:115284292-115308234 (+)
DBA/2J MGP_DBA2J_G0027548
 protein coding gene Chr3:103309751-103328234 (+)
FVB/NJ MGP_FVBNJ_G0027516
 protein coding gene Chr3:101234323-101251917 (+)
LP/J MGP_LPJ_G0027655
 protein coding gene Chr3:108894324-108915129 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027546
 protein coding gene Chr3:121380285-121410569 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028200
 protein coding gene Chr3:106228894-106249097 (+)
PWK/PhJ MGP_PWKPhJ_G0026613
 protein coding gene Chr3:103097169-103116155 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026434
 protein coding gene Chr3:104225156-104243603 (+)
WSB/EiJ MGP_WSBEiJ_G0026967
 protein coding gene Chr3:106765662-106786902 (+)



Homology
more
  • Human Ortholog
    CHIA, chitinase acidic
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHIA, chitinase acidic
  • Synonyms
    AMCASE, CHIT2, TSA1902
  • Links
    NCBI Gene ID: 27159
    neXtProt AC: NX_Q9BZP6
    UniProt: Q9BZP6

  • Chr Location
    1p13.2; chr1:111290851-111320566 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CHIA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout causes increased neutrophil and lymphocyte counts in bronchoalveolar lavage in certain pulmonary allergen exposure experiments, but immune response to various pulmonary allergen exposures is unchanged.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    808
  • Tissues
    96
  • cDNA Data
    692
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 81600 NCBI Gene Model | MGI Sequence Detail 18737 C57BL/6J ±  kb
    transcript NM_023186 RefSeq | MGI Sequence Detail 1557 FVB/N  
    polypeptide Q91XA9 UniProt | EBI | MGI Sequence Detail 473 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 693
      cDNA 692
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1913535
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 7
      Phenotypes 23
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory