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Vps36 Gene Detail
Summary
  • Symbol
    Vps36
  • Name
    vacuolar protein sorting 36
  • Synonyms
    1700010A24Rik, 2210415M20Rik, 2810408E15Rik, Eap45
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917410
    NCBI Gene: 70160
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:22682825-22710859 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 11.14 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    902 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917410
 protein coding gene Chr8:22682825-22710969 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033447
 protein coding gene Chr8:20037274-20066044 (+)
A/J MGP_AJ_G0033427
 protein coding gene Chr8:19384677-19412381 (+)
AKR/J MGP_AKRJ_G0033352
 protein coding gene Chr8:20015731-20046568 (+)
BALB/cJ MGP_BALBcJ_G0033423
 protein coding gene Chr8:19507142-19535826 (+)
C3H/HeJ MGP_C3HHeJ_G0033137
 protein coding gene Chr8:20215383-20243971 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033939
 protein coding gene Chr8:20886183-20917379 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030895
 protein coding gene Chr8:16716284-16744711 (+)
CAST/EiJ MGP_CASTEiJ_G0032463
 protein coding gene Chr8:19637180-19665036 (+)
CBA/J MGP_CBAJ_G0033112
 protein coding gene Chr8:21712728-21745405 (+)
DBA/2J MGP_DBA2J_G0033267
 protein coding gene Chr8:19353020-19381117 (+)
FVB/NJ MGP_FVBNJ_G0033211
 protein coding gene Chr8:19152965-19180807 (+)
LP/J MGP_LPJ_G0033356
 protein coding gene Chr8:20033625-20062158 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033254
 protein coding gene Chr8:21316186-21348717 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033958
 protein coding gene Chr8:19913729-19943980 (+)
PWK/PhJ MGP_PWKPhJ_G0032175
 protein coding gene Chr8:18942106-18971510 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032008
 protein coding gene Chr8:19305649-19332713 (+)
WSB/EiJ MGP_WSBEiJ_G0032579
 protein coding gene Chr8:20128223-20158781 (+)



Homology
more
  • Human Ortholog
    VPS36, vacuolar protein sorting 36 homolog
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VPS36, vacuolar protein sorting 36 homolog
  • Synonyms
    C13orf9, CGI-145, EAP45
  • Links
    NCBI Gene ID: 51028
    neXtProt AC: NX_Q86VN1
    UniProt: Q86VN1

  • Chr Location
    13q14.3; chr13:52412602-52450634 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    36
  • cDNA Data
    91
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031479 Ensembl Gene Model | MGI Sequence Detail 28035 C57BL/6J ±  kb
    transcript ENSMUST00000033866 Ensembl | MGI Sequence Detail 3574 Not Applicable  
    polypeptide ENSMUSP00000033866 Ensembl | MGI Sequence Detail 386 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000017334 vacuolar protein-sorting-associated protein 36
      (term hierarchy)
    • PDB
      2DX5
    • InterPro Domains
      IPR011993 PH-like domain superfamily
      IPR040608 Snf8/Vps36 family
      IPR037855 Vacuolar protein sorting protein 36
      IPR021648 Vacuolar protein sorting protein 36, GLUE domain
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    • GlyGen
      Q91XD6 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 93
      cDNA 91
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1922753, MGI:1923622
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 3
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory