Mtmr4 MGI Mouse Gene Detail - MGI:2180699 - myotubularin related protein 4

Symbol

Mtmr4
Name

myotubularin related protein 4
Synonyms

ESTM44, FYVE-DSP2, FYVE zinc finger phosphatase, mKIAA0647, ZFYVE11

Feature Type

protein coding gene
IDs

MGI:2180699
NCBI Gene: 170749
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:87482988-87507128 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 52.15 cM, cytoband C
Mapping Data

2 experiments

SNPs within 2kb

27 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2180699	protein coding gene	Chr11:87482769-87507128 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018907	protein coding gene	Chr11:89219875-89243996 (+)
A/J	MGP_AJ_G0018874	protein coding gene	Chr11:85775652-85799630 (+)
AKR/J	MGP_AKRJ_G0018844	protein coding gene	Chr11:88344804-88368931 (+)
BALB/cJ	MGP_BALBcJ_G0018847	protein coding gene	Chr11:86173210-86197163 (+)
C3H/HeJ	MGP_C3HHeJ_G0018661	protein coding gene	Chr11:88382285-88408007 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019299	protein coding gene	Chr11:91924574-91948987 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016932	protein coding gene	Chr11:82805193-82829357 (+)
CAST/EiJ	MGP_CASTEiJ_G0018216	protein coding gene	Chr11:89074086-89098249 (+)
CBA/J	MGP_CBAJ_G0018632	protein coding gene	Chr11:95782237-95806595 (+)
DBA/2J	MGP_DBA2J_G0018740	protein coding gene	Chr11:85329961-85353923 (+)
FVB/NJ	MGP_FVBNJ_G0018729	protein coding gene	Chr11:84837487-84861433 (+)
LP/J	MGP_LPJ_G0018810	protein coding gene	Chr11:89710364-89734479 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018756	protein coding gene	Chr11:95837970-95861951 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019339	protein coding gene	Chr11:88583564-88607693 (+)
PWK/PhJ	MGP_PWKPhJ_G0017986	protein coding gene	Chr11:86176874-86201684 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017779	protein coding gene	Chr11:88147774-88171774 (+)
WSB/EiJ	MGP_WSBEiJ_G0018267	protein coding gene	Chr11:88461716-88488812 (+)

Human Ortholog

MTMR4, myotubularin related protein 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MTMR4, myotubularin related protein 4
Synonyms

FYVE-DSP2, ZFYVE11
Links

HGNC:7452

NCBI Gene ID: 9110

neXtProt AC: NX_Q9NYA4

UniProt: Q9NYA4
Chr Location

17q22; chr17:58489529-58519047 (-) GRCh38

MGI Vertebrate Homology

Mtmr4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MTMR4
Gene Tree

Mtmr4

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

13
Targeted

4
Genomic Mutations

2 involving Mtmr4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

64 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

29
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

8
cDNA Data

11
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mtmr4

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All Sequences

80
RefSeq

26
UniProt

5
CCDS

CCDS25214.1, CCDS88215.1

Ensembl

ENSMUSG00000018401 (Evidence)
NCBI Gene

170749

			Length	Strain/Species	Flank
genomic	ENSMUSG00000018401	Ensembl Gene Model \| MGI Sequence Detail	24141	C57BL/6J	± kb
transcript	ENSMUST00000103179	Ensembl \| MGI Sequence Detail	5753	Not Applicable
polypeptide	ENSMUSP00000099468	Ensembl \| MGI Sequence Detail	1190	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000010738 myotubularin-related protein 4

(term hierarchy)
EC

3.1.3.64, 3.1.3.95
InterPro Domains

IPR000306 FYVE zinc finger

IPR035997 MTMR4, PH-GRAM domain

IPR030564 Myotubularin family

IPR010569 Myotubularin-like, phosphatase domain

IPR046978 Myotubularin-related protein 4, FYVE domain

IPR030590 Myotubularin-related protein 4, protein tyrosine phosphatase domain

IPR016130 Protein-tyrosine phosphatase, active site

IPR003595 Protein-tyrosine phosphatase, catalytic

IPR029021 Protein-tyrosine phosphatase-like

IPR000387 Tyrosine-specific protein phosphatases domain

IPR011011 Zinc finger, FYVE/PHD-type

IPR017455 Zinc finger, FYVE-related

IPR013083 Zinc finger, RING/FYVE/PHD-type

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All nucleic 13

cDNA 12

Primer pair 1

Microarray probesets 6

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MGI:1334430

Summaries

All 53

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 20
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:351573 Sasner M, et al., In vivo validation of late-onset Alzheimer's disease genetic risk factors. Alzheimers Dement. 2024 Jul;20(7):4970-4984

TSS for Mtmr4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103941	Chr11:87482971-87483055 (+)	25 bp
Tssr103942	Chr11:87483467-87483498 (+)	495 bp
Tssr103943	Chr11:87483770-87483832 (+)	813 bp
Tssr103944	Chr11:87484415-87484419 (+)	1,429 bp
Tssr103945	Chr11:87486472-87486485 (+)	3,491 bp
Tssr103946	Chr11:87486490-87486545 (+)	3,530 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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