Mapk8 MGI Mouse Gene Detail - MGI:1346861 - mitogen-activated protein kinase 8

Symbol

Mapk8
Name

mitogen-activated protein kinase 8
Synonyms

c-Jun N-terminal kinase, JNK1, Prkm8

Feature Type

protein coding gene
IDs

MGI:1346861
NCBI Gene: 26419
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr14:33099855-33169115 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 20.22 cM, cytoband B
Mapping Data

3 experiments

SNPs within 2kb

1224 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346861	protein coding gene	Chr14:33099855-33169213 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021156	protein coding gene	Chr14:26678871-26758649 (-)
A/J	MGP_AJ_G0021104	protein coding gene	Chr14:25657706-25727463 (-)
AKR/J	MGP_AKRJ_G0021081	protein coding gene	Chr14:26801233-26876795 (-)
BALB/cJ	MGP_BALBcJ_G0021108	protein coding gene	Chr14:25825210-25896079 (-)
C3H/HeJ	MGP_C3HHeJ_G0020891	protein coding gene	Chr14:26710556-26781137 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021540	protein coding gene	Chr14:27731502-27806679 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019102	protein coding gene	Chr14:25694461-25771061 (-)
CAST/EiJ	MGP_CASTEiJ_G0020416	protein coding gene	Chr14:26522552-26593003 (-)
CBA/J	MGP_CBAJ_G0020858	protein coding gene	Chr14:28757961-28828385 (-)
DBA/2J	MGP_DBA2J_G0020980	protein coding gene	Chr14:25695092-25763337 (-)
FVB/NJ	MGP_FVBNJ_G0020964	protein coding gene	Chr14:25645475-25713414 (-)
LP/J	MGP_LPJ_G0021049	protein coding gene	Chr14:26998550-27070194 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020990	protein coding gene	Chr14:27919876-27996228 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021573	protein coding gene	Chr14:26624831-26704895 (-)
PWK/PhJ	MGP_PWKPhJ_G0020164	protein coding gene	Chr14:25164841-25238683 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019988	protein coding gene	Chr14:26259908-26330137 (-)
WSB/EiJ	MGP_WSBEiJ_G0020471	protein coding gene	Chr14:26692041-26765465 (-)

Human Ortholog

MAPK8, mitogen-activated protein kinase 8

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAPK8, mitogen-activated protein kinase 8
Synonyms

JNK, JNK1, JNK1A2, JNK21B1/2, JNK-46, PRKM8, SAPK1, SAPK1c
Links

HGNC:6881

NCBI Gene ID: 5599

neXtProt AC: NX_P45983

UniProt: P45983
Chr Location

10q11.22; chr10:48306639-48439360 (+) GRCh38

MGI Vertebrate Homology

Mapk8 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MAPK8
Gene Tree

Mapk8

Diseases

5 with human MAPK8 associations

				Human Disease	Mouse Models
				abdominal aortic aneurysm IDs abdominal aortic aneurysm DOID:7693 EFO:0004214 MESH:D017544 NCI:C27000 OMIM:100070 OMIM:609782 OMIM:611891 OMIM:614375 UMLS_CUI:C0162871
				chronic mucocutaneous candidiasis IDs chronic mucocutaneous candidiasis DOID:2058 DOID:2056 MESH:D002178 NCI:C34444 OMIM:114580 OMIM:212050 OMIM:607644 OMIM:613108 OMIM:613956 OMIM:614162 OMIM:615527 OMIM:616445 ORDO:1334 UMLS_CUI:C0006845
				colorectal adenoma IDs colorectal adenoma DOID:0050860
				rectal benign neoplasm IDs rectal benign neoplasm DOID:1984 MESH:D012004 NCI:C3350 UMLS_CUI:C0034885
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

52 phenotypes from 4 alleles in 10 genetic backgrounds
95 phenotypes from multigenic genotypes
4 images
219 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

35
Endonuclease-mediated

6
Gene trapped

23
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

74 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit abnormal T cell differentiation and proliferation, cardiac morphology and physiology, and chemically-induced tumorigenesis. Mice homozygous for another knock-out allele exhibit abnormal glucose homeostasis and T cell physiology. KO also leads to an increased number of retinal photoreceptor cells.

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All GO Annotations

125
GO References

48

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1139
Tissues

137
cDNA Data

82
Literature Summary

155

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MAPK8

Xenbase mapk8

ZFIN mapk8a, mapk8b

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All Sequences

85
RefSeq

13
UniProt

8
CCDS

CCDS36869.1, CCDS79293.1, CCDS79295.1, CCDS84111.1

Ensembl

ENSMUSG00000021936 (Evidence)
NCBI Gene

26419

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021936	Ensembl Gene Model \| MGI Sequence Detail	69261	C57BL/6J	± kb
transcript	ENSMUST00000022504	Ensembl \| MGI Sequence Detail	2587	Not Applicable
polypeptide	ENSMUSP00000022504	Ensembl \| MGI Sequence Detail	427	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000002206 mitogen-activated protein kinase 8

(term hierarchy)
EC

2.7.11.24
InterPro Domains

IPR050117 Mitogen-activated protein kinase

IPR003527 Mitogen-activated protein (MAP) kinase, conserved site

IPR008351 Mitogen-activated protein (MAP) kinase, JNK

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 91

Genomic 1

cDNA 85

Primer pair 4

Other 1

Microarray probesets 12

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MGI:1328367, MGI:2145699

Summaries

All 624

Developmental Gene Expression 155

Diseases 1

Gene Ontology 48

Phenotypes 219
Earliest

J:41744 Tournier C, et al., Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7337-42
Latest

J:352991 Wang J, et al., Crosstalk of MAP3K1 and EGFR signaling mediates gene-environment interactions that block developmental tissue closure. J Biol Chem. 2024 Jul;300(7):107486

TSS for Mapk8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr128039	Chr14:33169141-33169157 (-)	-34 bp
Tssr128038	Chr14:33169099-33169136 (-)	-3 bp
Tssr128037	Chr14:33169077-33169090 (-)	31 bp
Tssr128036	Chr14:33104789-33104793 (-)	64,324 bp
Tssr128035	Chr14:33104094-33104102 (-)	65,017 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24