Tent2 MGI Mouse Gene Detail - MGI:2140950 - terminal nucleotidyltransferase 2

Symbol

Tent2
Name

terminal nucleotidyltransferase 2
Synonyms

8030446C20Rik, Papd4

Feature Type

protein coding gene
IDs

MGI:2140950
NCBI Gene: 100715
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr13:93282790-93328893 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 47.81 cM
Mapping Data

3 experiments

SNPs within 2kb

1132 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2140950	protein coding gene	Chr13:93282363-93330662 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020823	protein coding gene	Chr13:94481271-94529133 (-)
A/J	MGP_AJ_G0020777	protein coding gene	Chr13:90967467-91018893 (-)
AKR/J	MGP_AKRJ_G0020750	protein coding gene	Chr13:93733921-93779788 (-)
BALB/cJ	MGP_BALBcJ_G0020773	protein coding gene	Chr13:91627257-91672090 (-)
C3H/HeJ	MGP_C3HHeJ_G0020567	protein coding gene	Chr13:93435253-93480770 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021210	protein coding gene	Chr13:97363500-97409672 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018777	protein coding gene	Chr13:86871837-86916788 (-)
CAST/EiJ	MGP_CASTEiJ_G0020086	protein coding gene	Chr13:92694924-92741437 (-)
CBA/J	MGP_CBAJ_G0020526	protein coding gene	Chr13:101211764-101270917 (-)
DBA/2J	MGP_DBA2J_G0020651	protein coding gene	Chr13:90756611-90801622 (-)
FVB/NJ	MGP_FVBNJ_G0020631	protein coding gene	Chr13:89552702-89597519 (-)
LP/J	MGP_LPJ_G0020724	protein coding gene	Chr13:94594112-94640882 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020660	protein coding gene	Chr13:101690290-101762872 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021250	protein coding gene	Chr13:93131449-93177850 (-)
PWK/PhJ	MGP_PWKPhJ_G0019838	protein coding gene	Chr13:89458243-89510192 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019662	protein coding gene	Chr13:89402591-89454942 (-)
WSB/EiJ	MGP_WSBEiJ_G0020143	protein coding gene	Chr13:93622559-93669704 (-)

Human Ortholog

TENT2, terminal nucleotidyltransferase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TENT2, terminal nucleotidyltransferase 2
Synonyms

APD4, GLD2, PAPD4, TUT2
Links

HGNC:26776

NCBI Gene ID: 167153

neXtProt AC: NX_Q6PIY7

UniProt: Q6PIY7
Chr Location

5q14.1; chr5:79612120-79688246 (+) GRCh38

MGI Vertebrate Homology

Tent2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TENT2
Gene Tree

Tent2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

59
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

53
Targeted

2
Genomic Mutations

1 involving Tent2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

40 strains or lines available

Mice homozygous for a null allele reuslts in disruption in polyadenylation in oocytes and somatic cells.

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All GO Annotations

28
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

7
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tent2

ZFIN tent2

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All Sequences

55
RefSeq

13
UniProt

4
CCDS

CCDS26686.1, CCDS88498.1

Ensembl

ENSMUSG00000042167 (Evidence)
NCBI Gene

100715

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042167	Ensembl Gene Model \| MGI Sequence Detail	46104	C57BL/6J	± kb
transcript	ENSMUST00000048702	Ensembl \| MGI Sequence Detail	2990	Not Applicable
polypeptide	ENSMUSP00000048124	Ensembl \| MGI Sequence Detail	484	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000012263 poly(A) RNA polymerase GLD2

(term hierarchy)
PDB

6LBJ
EC

2.7.7.19
InterPro Domains

IPR043519 Nucleotidyltransferase superfamily

IPR002058 PAP/25A-associated

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All nucleic 7

cDNA 7

Microarray probesets 5

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MGI:6192087

Summaries

All 46

Developmental Gene Expression 1

Gene Ontology 10

Phenotypes 13
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Tent2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr123454	Chr13:93328933-93328940 (-)	-44 bp
Tssr123453	Chr13:93328883-93328932 (-)	-15 bp
Tssr123452	Chr13:93328778-93328836 (-)	86 bp
Tssr123451	Chr13:93328747-93328771 (-)	134 bp
Tssr123450	Chr13:93328725-93328745 (-)	158 bp
Tssr123449	Chr13:93328701-93328708 (-)	188 bp
Tssr123448	Chr13:93325353-93325358 (-)	3,537 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24