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Ythdf2 Gene Detail
Summary
  • Symbol
    Ythdf2
  • Name
    YTH N6-methyladenosine RNA binding protein 2
  • Synonyms
    9430020E02Rik, HGRG8, NY-REN-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444233
    NCBI Gene: 213541
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:131912227-131939567 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 64.92 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    628 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444233
 protein coding gene Chr4:131912223-131939614 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028864
 protein coding gene Chr4:134318717-134347065 (-)
A/J MGP_AJ_G0028823
 protein coding gene Chr4:128736634-128765077 (-)
AKR/J MGP_AKRJ_G0028776
 protein coding gene Chr4:132347984-132380223 (-)
BALB/cJ MGP_BALBcJ_G0028846
 protein coding gene Chr4:129346808-129374434 (-)
C3H/HeJ MGP_C3HHeJ_G0028560
 protein coding gene Chr4:132598812-132627124 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029288
 protein coding gene Chr4:139150168-139184026 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026560
 protein coding gene Chr4:121842045-121850148 (-)
CAST/EiJ MGP_CASTEiJ_G0027993
 protein coding gene Chr4:130670342-130700335 (-)
CBA/J MGP_CBAJ_G0028526
 protein coding gene Chr4:142714575-142753206 (-)
DBA/2J MGP_DBA2J_G0028675
 protein coding gene Chr4:129161182-129189152 (-)
FVB/NJ MGP_FVBNJ_G0028642
 protein coding gene Chr4:128010934-128037853 (-)
LP/J MGP_LPJ_G0028776
 protein coding gene Chr4:134471439-134498544 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028668
 protein coding gene Chr4:147325233-147352799 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029326
 protein coding gene Chr4:132753182-132780958 (-)
PWK/PhJ MGP_PWKPhJ_G0027714
 protein coding gene Chr4:125836064-125864580 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027540
 protein coding gene Chr4:128624561-128654162 (-)
WSB/EiJ MGP_WSBEiJ_G0028073
 protein coding gene Chr4:132946000-132957781 (-)



Homology
more
  • Human Ortholog
    YTHDF2, YTH N6-methyladenosine RNA binding protein F2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    YTHDF2, YTH N6-methyladenosine RNA binding protein F2
  • Synonyms
    CAHL, DF2, HGRG8, NY-REN-2
  • Links
    NCBI Gene ID: 51441
    neXtProt AC: NX_Q9Y5A9
    UniProt: Q9Y5A9

  • Chr Location
    1p35.3; chr1:28736621-28769775 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozgyous for a knock-out allele exhibit female, but not male, infertility and preweaning lethality that is background sensitive. Homozygous KO male mice are hypo-fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    6
  • cDNA Data
    17
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 213541 NCBI Gene Model | MGI Sequence Detail 27341 C57BL/6J ±  kb
    transcript NM_145393 RefSeq | MGI Sequence Detail 4078 C57BL/6  
    polypeptide Q91YT7 UniProt | EBI | MGI Sequence Detail 579 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 35
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory