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Hyal1 Gene Detail
Summary
  • Symbol
    Hyal1
  • Name
    hyaluronoglucosaminidase 1
  • Synonyms
    Hyal-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96298
    NCBI Gene: 15586
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107454149-107458898 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 58.17 cM, cytoband F1-F2
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    162 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96298
 protein coding gene Chr9:107454126-107458909 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035260
 protein coding gene Chr9:109457502-109462280 (+)
A/J MGP_AJ_G0035239
 protein coding gene Chr9:105473939-105478714 (+)
AKR/J MGP_AKRJ_G0035171
 protein coding gene Chr9:108107595-108112369 (+)
BALB/cJ MGP_BALBcJ_G0035233
 protein coding gene Chr9:105143212-105147986 (+)
C3H/HeJ MGP_C3HHeJ_G0034943
 protein coding gene Chr9:108505236-108510010 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035753
 protein coding gene Chr9:112443917-112448682 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032651
 protein coding gene Chr9:102903558-102908213 (+)
CAST/EiJ MGP_CASTEiJ_G0034254
 protein coding gene Chr9:108437844-108442623 (+)
CBA/J MGP_CBAJ_G0034911
 protein coding gene Chr9:116417720-116422573 (+)
DBA/2J MGP_DBA2J_G0035072
 protein coding gene Chr9:104927591-104932390 (+)
FVB/NJ MGP_FVBNJ_G0035020
 protein coding gene Chr9:103693006-103697787 (+)
LP/J MGP_LPJ_G0035148
 protein coding gene Chr9:109658607-109663385 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035059
 protein coding gene Chr9:118030064-118034839 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035774
 protein coding gene Chr9:108379208-108383988 (+)
PWK/PhJ MGP_PWKPhJ_G0033961
 protein coding gene Chr9:105248109-105252954 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033796
 protein coding gene Chr9:108433448-108438191 (+)
WSB/EiJ MGP_WSBEiJ_G0034375
 protein coding gene Chr9:108260589-108265268 (+)



Homology
more
  • Human Ortholog
    HYAL1, hyaluronidase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HYAL1, hyaluronidase 1
  • Synonyms
    HYAL-1, LUCA1, MPS9, NAT6
  • Links
    NCBI Gene ID: 3373
    neXtProt AC: NX_Q12794
    UniProt: Q12794

  • Chr Location
    3p21.31; chr3:50299890-50312381 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hyal1 mouse models; 2 with human HYAL1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display a progressive osteoarthritis associated with bony outgrowths, early loss of articular cartilage proteoglycans and accumulation of hyaluronan (HA) in the cartilage of knee joints, but show no signs of non-skeletal tissue GAG accumulation or increased serum HA levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    814
  • Tissues
    105
  • cDNA Data
    10
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15586 NCBI Gene Model | MGI Sequence Detail 4750 C57BL/6J ±  kb
    transcript NM_008317 RefSeq | MGI Sequence Detail 2995 ZRU/MplStud  
    polypeptide Q91ZJ9 UniProt | EBI | MGI Sequence Detail 462 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 2
      cDNA 11
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11032, MGD-MRK-11033
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 10
      Phenotypes 17
    • Earliest
      J:9611 Fiszer-Szafarz B, et al., Hyal-1, a locus determining serum hyaluronidase polymorphism, on chromosome 9 in mice. Somat Cell Mol Genet. 1989 Jan;15(1):79-83
    • Latest
      J:346912 Huang H, et al., Hyaluronan degradation by HYAL2 is essential for odontoblastic differentiation and migration of mouse dental papilla cells. Matrix Biol. 2024 Mar 13;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory