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Crebzf Gene Detail
Summary
  • Symbol
    Crebzf
  • Name
    CREB/ATF bZIP transcription factor
  • Synonyms
    1110034C16Rik, 6330417B10Rik, LAZip, LAZipII, Zf
  • Feature Type
    protein coding gene
  • IDs
    MGI:2675296
    NCBI Gene: 233490
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:90091937-90097202 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 50.59 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    142 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2675296
 protein coding gene Chr7:90091937-90097590 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032507
 protein coding gene Chr7:92868073-92874317 (+)
A/J MGP_AJ_G0032481
 protein coding gene Chr7:90628729-90633730 (+)
AKR/J MGP_AKRJ_G0032417
 protein coding gene Chr7:92753439-92758098 (+)
BALB/cJ MGP_BALBcJ_G0032492
 protein coding gene Chr7:90275182-90280170 (+)
C3H/HeJ MGP_C3HHeJ_G0032207
 protein coding gene Chr7:93134187-93141654 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032990
 protein coding gene Chr7:96494709-96499907 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029985
 protein coding gene Chr7:93511432-93516418 (+)
CAST/EiJ MGP_CASTEiJ_G0031534
 protein coding gene Chr7:84574798-84579788 (+)
CBA/J MGP_CBAJ_G0032174
 protein coding gene Chr7:99706779-99712211 (+)
DBA/2J MGP_DBA2J_G0032326
 protein coding gene Chr7:89063333-89068193 (+)
FVB/NJ MGP_FVBNJ_G0032282
 protein coding gene Chr7:88931306-88936395 (+)
LP/J MGP_LPJ_G0032415
 protein coding gene Chr7:94141163-94146145 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032316
 protein coding gene Chr7:100712774-100718376 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033012
 protein coding gene Chr7:92031068-92036637 (+)
PWK/PhJ MGP_PWKPhJ_G0031252
 protein coding gene Chr7:82103781-82108793 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031095
 protein coding gene Chr7:79351637-79357727 (+)
WSB/EiJ MGP_WSBEiJ_G0031651
 protein coding gene Chr7:92703290-92709640 (+)



Homology
more
  • Human Ortholog
    CREBZF, CREB/ATF bZIP transcription factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CREBZF, CREB/ATF bZIP transcription factor
  • Synonyms
    SMILE, ZF
  • Links
    NCBI Gene ID: 58487
    neXtProt AC: NX_Q9NS37
    UniProt: Q9NS37

  • Chr Location
    11q14.1; chr11:85657742-85682908 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1006
  • Tissues
    169
  • cDNA Data
    111
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000051451 Ensembl Gene Model | MGI Sequence Detail 5266 C57BL/6J ±  kb
transcript ENSMUST00000061767 Ensembl | MGI Sequence Detail 3376 Not Applicable  
polypeptide ENSMUSP00000050972 Ensembl | MGI Sequence Detail 358 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 114
    cDNA 112
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:1915908, MGI:1917971, MGI:2141880, MGI:2142010
References
more
  • Summaries
    All 69
    Developmental Gene Expression 8
    Gene Ontology 5
    Phenotypes 31
  • Earliest
    J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
  • Latest
    J:347869 Liu Y, et al., Macrophage CREBZF Orchestrates Inflammatory Response to Potentiate Insulin Resistance and Type 2 Diabetes. Adv Sci (Weinh). 2024 Apr;11(13):e2306685
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory