About   Help   FAQ
Nek8 Gene Detail
Summary
  • Symbol
    Nek8
  • Name
    NIMA (never in mitosis gene a)-related expressed kinase 8
  • Synonyms
    4632401F23Rik, b2b1449Clo
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890646
    NCBI Gene: 140859
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:78056932-78067501 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 46.74 cM, cytoband B5
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    246 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890646
 protein coding gene Chr11:78056932-78067501 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018765
 protein coding gene Chr11:79147776-79158305 (-)
A/J MGP_AJ_G0018731
 protein coding gene Chr11:76124897-76135462 (-)
AKR/J MGP_AKRJ_G0018701
 protein coding gene Chr11:78429056-78440573 (-)
BALB/cJ MGP_BALBcJ_G0018705
 protein coding gene Chr11:76534127-76544680 (-)
C3H/HeJ MGP_C3HHeJ_G0018518
 protein coding gene Chr11:78470276-78481658 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019156
 protein coding gene Chr11:81619373-81629923 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016791
 protein coding gene Chr11:73098694-73109440 (-)
CAST/EiJ MGP_CASTEiJ_G0018072
 protein coding gene Chr11:78908328-78918795 (-)
CBA/J MGP_CBAJ_G0018488
 protein coding gene Chr11:85178620-85191841 (-)
DBA/2J MGP_DBA2J_G0018597
 protein coding gene Chr11:75706938-75717608 (-)
FVB/NJ MGP_FVBNJ_G0018587
 protein coding gene Chr11:75294162-75305458 (-)
LP/J MGP_LPJ_G0018668
 protein coding gene Chr11:79683488-79694045 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018613
 protein coding gene Chr11:85603620-85614018 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019196
 protein coding gene Chr11:78672859-78683417 (-)
PWK/PhJ MGP_PWKPhJ_G0017843
 protein coding gene Chr11:76488737-76499305 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017634
 protein coding gene Chr11:78280814-78291188 (-)
WSB/EiJ MGP_WSBEiJ_G0018125
 protein coding gene Chr11:78486604-78496984 (-)



Homology
more
  • Human Ortholog
    NEK8, NIMA related kinase 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEK8, NIMA related kinase 8
  • Synonyms
    JCK, NEK12A, NPHP9, PKD8, RHPD2
  • Links
    NCBI Gene ID: 284086
    neXtProt AC: NX_Q86SG6
    UniProt: Q86SG6

  • Chr Location
    17q11.2; chr17:28725897-28743455 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Nek8 mouse models; 2 with human NEK8 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 4 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    8 images
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice display kidney cysts primarily in the cortex, progressive kidney enlargement, increased serum creatinine levels, impaired maternal nurturing, and premature death. Heterotaxy with congenital heart disease such as hypoplastic right ventricle and small tricuspid valve is seen.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    750
  • Tissues
    16
  • cDNA Data
    28
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 140859 NCBI Gene Model | MGI Sequence Detail 10570 C57BL/6J ±  kb
    transcript NM_080849 RefSeq | MGI Sequence Detail 2832 ZRU/MplStud  
    polypeptide Q91ZR4 UniProt | EBI | MGI Sequence Detail 698 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • EC
      2.7.11.1
    • InterPro Domains
      IPR044120 Nek8, catalytic domain
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
      IPR000408 Regulator of chromosome condensation, RCC1
      IPR008271 Serine/threonine-protein kinase, active site
      IPR051997 Serine/threonine-protein kinase NEK
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 28
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11520, MGI:1921589, MGI:5317582, MGI:96632
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 16
      Phenotypes 45
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:337557 Swenson-Fields KI, et al., Caspase-1 and the inflammasome promote polycystic kidney disease progression. Front Mol Biosci. 2022;9:971219
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory