Optc MGI Mouse Gene Detail - MGI:2151113

Symbol

Optc
Name

opticin

Feature Type

protein coding gene
IDs

MGI:2151113
NCBI Gene: 269120
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr1:133824937-133835737 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 58.02 cM
Mapping Data

3 experiments

SNPs within 2kb

386 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2151113	protein coding gene	Chr1:133824937-133837344 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016494	protein coding gene	Chr1:137528182-137538965 (-)
A/J	MGP_AJ_G0016477	protein coding gene	Chr1:132361015-132371811 (-)
AKR/J	MGP_AKRJ_G0016442	protein coding gene	Chr1:136303361-136314271 (-)
BALB/cJ	MGP_BALBcJ_G0016437	protein coding gene	Chr1:132692886-132703684 (-)
C3H/HeJ	MGP_C3HHeJ_G0016263	protein coding gene	Chr1:136402751-136414601 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016898	protein coding gene	Chr1:142554168-142564968 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014609	protein coding gene	Chr1:125506327-125518169 (-)
CAST/EiJ	MGP_CASTEiJ_G0015843	protein coding gene	Chr1:135449142-135460043 (-)
CBA/J	MGP_CBAJ_G0016236	protein coding gene	Chr1:147446457-147457253 (-)
DBA/2J	MGP_DBA2J_G0016342	protein coding gene	Chr1:131375175-131385975 (-)
FVB/NJ	MGP_FVBNJ_G0016341	protein coding gene	Chr1:129997736-130008526 (-)
LP/J	MGP_LPJ_G0016413	protein coding gene	Chr1:138797302-138808100 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016366	protein coding gene	Chr1:153189162-153201571 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016934	protein coding gene	Chr1:136027526-136039401 (-)
PWK/PhJ	MGP_PWKPhJ_G0015629	protein coding gene	Chr1:130384012-130394902 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015416	protein coding gene	Chr1:134995074-135005825 (-)
WSB/EiJ	MGP_WSBEiJ_G0015906	protein coding gene	Chr1:136056530-136067312 (-)

Human Ortholog

OPTC, opticin

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OPTC, opticin
Synonyms

OPT
Links

HGNC:8158

NCBI Gene ID: 26254

neXtProt AC: NX_Q9UBM4

UniProt: Q9UBM4
Chr Location

1q32.1; chr1:203494153-203508949 (+) GRCh38

MGI Vertebrate Homology

Optc stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: OPTC
Gene Tree

Optc

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

2
Endonuclease-mediated

1
Radiation induced

1
Targeted

3
Genomic Mutations

3 involving Optc
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased preretinal neovascularization in an oxygen-induced retinopathy model.

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All GO Annotations

11
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

8
cDNA Data

8
Literature Summary

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA OPTC

Xenbase optc

ZFIN optc

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All Sequences

80
RefSeq

35
UniProt

7
CCDS

CCDS15299.2, CCDS48366.1

Ensembl

ENSMUSG00000010311 (Evidence)
NCBI Gene

269120

			Length	Strain/Species	Flank
genomic	ENSMUSG00000010311	Ensembl Gene Model \| MGI Sequence Detail	10801	C57BL/6J	± kb
transcript	ENSMUST00000124051	Ensembl \| MGI Sequence Detail	1885	Not Applicable
polypeptide	ENSMUSP00000120568	Ensembl \| MGI Sequence Detail	381	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000011651 opticin

(term hierarchy)
InterPro Domains

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

IPR043547 Mimecan/Epiphycan/Opticin
GlyGen

Q920A0 6 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 14

Genomic 4

cDNA 9

Primer pair 1

Microarray probesets 3

Summaries

All 39

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 11
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Optc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr13724	Chr1:133834791-133834800 (-)	941 bp
Tssr13723	Chr1:133834711-133834752 (-)	1,005 bp
Tssr13722	Chr1:133834692-133834698 (-)	1,042 bp
Tssr13721	Chr1:133826953-133826988 (-)	8,766 bp
Tssr13720	Chr1:133826926-133826952 (-)	8,798 bp
Tssr13719	Chr1:133826890-133826911 (-)	8,836 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24