Supt16 MGI Mouse Gene Detail - MGI:1890948 - SPT16, facilitates chromatin remodeling subunit

Symbol

Supt16
Name

SPT16, facilitates chromatin remodeling subunit
Synonyms

Cdc68, Fact140, Spt16, Supt16h

Feature Type

protein coding gene
IDs

MGI:1890948
NCBI Gene: 114741
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr14:52397876-52434696 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 26.83 cM
Mapping Data

1 experiment

SNPs within 2kb

737 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1890948	protein coding gene	Chr14:52397871-52434873 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021292	protein coding gene	Chr14:46192699-46229529 (-)
A/J	MGP_AJ_G0021249	protein coding gene	Chr14:44979738-45015836 (-)
AKR/J	MGP_AKRJ_G0021225	protein coding gene	Chr14:46603392-46639462 (-)
BALB/cJ	MGP_BALBcJ_G0021253	protein coding gene	Chr14:45086790-45122997 (-)
C3H/HeJ	MGP_C3HHeJ_G0021033	protein coding gene	Chr14:46415284-46451764 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021692	protein coding gene	Chr14:48239671-48281619 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019236	protein coding gene	Chr14:44183737-44217801 (-)
CAST/EiJ	MGP_CASTEiJ_G0020552	protein coding gene	Chr14:43388350-43424636 (-)
CBA/J	MGP_CBAJ_G0021000	protein coding gene	Chr14:49693866-49733225 (-)
DBA/2J	MGP_DBA2J_G0021121	protein coding gene	Chr14:44752612-44788727 (-)
FVB/NJ	MGP_FVBNJ_G0021104	protein coding gene	Chr14:44334076-44371140 (-)
LP/J	MGP_LPJ_G0021196	protein coding gene	Chr14:46787965-46824917 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021127	protein coding gene	Chr14:49150512-49187029 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021719	protein coding gene	Chr14:45989500-46027012 (-)
PWK/PhJ	MGP_PWKPhJ_G0020301	protein coding gene	Chr14:41492361-41528929 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020128	protein coding gene	Chr14:42026101-42062696 (-)
WSB/EiJ	MGP_WSBEiJ_G0020605	protein coding gene	Chr14:46312833-46353655 (-)

Human Ortholog

SUPT16H, SPT16 homolog, facilitates chromatin remodeling subunit

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SUPT16H, SPT16 homolog, facilitates chromatin remodeling subunit
Synonyms

CDC68, FACTP140, NEDDFAC, SPT16, SPT16/CDC68
Links

HGNC:11465

NCBI Gene ID: 11198

neXtProt AC: NX_Q9Y5B9

UniProt: Q9Y5B9
Chr Location

14q11.2

MGI Vertebrate Homology

Supt16 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SUPT16H
Gene Tree

Supt16

Diseases

1 with human SUPT16H associations

				Human Disease	Mouse Models
				neurodevelopmental disorder with dysmorphic facies and thin corpus callosum IDs neurodevelopmental disorder with dysmorphic facies and thin corpus callosum DOID:0070469 OMIM:619480

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

15 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

52
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

46
Genomic Mutations

1 involving Supt16
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

76 strains or lines available

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All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1042
Tissues

144
cDNA Data

15
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase supt16h

ZFIN supt16h

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All Sequences

43
RefSeq

2
UniProt

2
CCDS

CCDS27051.1

Ensembl

ENSMUSG00000035726 (Evidence)
NCBI Gene

114741

			Length	Strain/Species	Flank
genomic	114741	NCBI Gene Model \| MGI Sequence Detail	36821	C57BL/6J	± kb
transcript	NM_033618	RefSeq \| MGI Sequence Detail	4491	ZRU/MplStud
polypeptide	Q920B9	UniProt \| EBI \| MGI Sequence Detail	1047	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000015834 FACT complex subunit SPT16

(term hierarchy)
InterPro Domains

IPR036005 Creatinase/aminopeptidase-like

IPR029149 Creatinase/Aminopeptidase P/Spt16, N-terminal

IPR040258 FACT complex subunit Spt16

IPR048969 FACT complex subunit SPT16, C-terminal domain

IPR013953 FACT complex subunit Spt16 domain

IPR029148 FACT complex subunit Spt16, N-terminal lobe domain

IPR033825 FACT complex subunit Spt16, peptidase M24-like domain

IPR013719 Histone chaperone RTT106/FACT complex subunit SPT16-like, middle domain

IPR000994 Peptidase M24

IPR011993 PH-like domain superfamily
GlyGen

Q920B9 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 18

cDNA 16

Primer pair 2

Microarray probesets 5

Summaries

All 40

Developmental Gene Expression 5

Gene Ontology 5

Phenotypes 11
Earliest

J:70807 McGuire MV, et al., The mouse Supt16h/Fact140 gene, encoding part of the FACT chromatin transcription complex, maps close to Tcra and is highly expressed in thymus. Mamm Genome. 2001 Aug;12(8):664-7
Latest

J:344671 Wang J, et al., Supt16 haploinsufficiency causes neurodevelopment disorder by disrupting MAPK pathway in neural stem cells. Hum Mol Genet. 2023 Feb 19;32(5):860-872

TSS for Supt16:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr128503	Chr14:52434862-52434922 (-)	-196 bp
Tssr128502	Chr14:52434673-52434724 (-)	-3 bp
Tssr128501	Chr14:52434639-52434664 (-)	44 bp
Tssr128500	Chr14:52434607-52434630 (-)	77 bp
Tssr128499	Chr14:52417696-52417709 (-)	16,993 bp
Tssr128498	Chr14:52417671-52417694 (-)	17,013 bp
Tssr128497	Chr14:52417629-52417646 (-)	17,058 bp
Tssr128496	Chr14:52412738-52412742 (-)	21,956 bp
Tssr128495	Chr14:52398382-52398386 (-)	36,312 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24