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Siglecf Gene Detail
Summary
  • Symbol
    Siglecf
  • Name
    sialic acid binding Ig-like lectin F
  • Synonyms
    mSiglec-F, Siglec5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2681107
    NCBI Gene: 233186
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:43000765-43008955 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.25 cM, cytoband B3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    279 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2681107
 protein coding gene Chr7:43000496-43008955 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032118
 protein coding gene Chr7:43359026-43367204 (+)
A/J MGP_AJ_G0032103
 protein coding gene Chr7:42477370-42485541 (+)
AKR/J MGP_AKRJ_G0032033
 protein coding gene Chr7:43845900-43854084 (+)
BALB/cJ MGP_BALBcJ_G0032108
 protein coding gene Chr7:42590096-42598286 (+)
C3H/HeJ MGP_C3HHeJ_G0031824
 protein coding gene Chr7:44339375-44347569 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032592
 protein coding gene Chr7:45547408-45555543 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029615
 protein coding gene Chr7:44598299-44606945 (+)
CAST/EiJ MGP_CASTEiJ_G0031154
 protein coding gene Chr7:35512124-35522444 (+)
CBA/J MGP_CBAJ_G0031793
 protein coding gene Chr7:46972675-46981095 (+)
DBA/2J MGP_DBA2J_G0031942
 protein coding gene Chr7:42277677-42285968 (+)
FVB/NJ MGP_FVBNJ_G0031903
 protein coding gene Chr7:41996828-42005007 (+)
LP/J MGP_LPJ_G0032021
 protein coding gene Chr7:44090276-44098446 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031939
 protein coding gene Chr7:45942165-45950319 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032612
 protein coding gene Chr7:42961561-42969691 (+)
PWK/PhJ MGP_PWKPhJ_G0030875
 protein coding gene Chr7:35707594-35716320 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030714
 protein coding gene Chr7:31022669-31030792 (+)
WSB/EiJ MGP_WSBEiJ_G0031268
 protein coding gene Chr7:43514930-43523118 (+)



Homology
more
  • Human Ortholog
    SIGLEC14, sialic acid binding Ig like lectin 14
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIGLEC14, sialic acid binding Ig like lectin 14
  • Links
    NCBI Gene ID: 100049587
    neXtProt AC: NX_Q08ET2
    UniProt: Q08ET2

  • Chr Location
    19q13.41; chr19:51639478-51646825 (-)  GRCh38
  • Human Ortholog
    SIGLEC5, sialic acid binding Ig like lectin 5
  • Synonyms
    CD170, CD33L2, OB-BP2, OBBP2, SIGLEC-5
  • Links
    NCBI Gene ID: 8778
    neXtProt AC: NX_O15389
    UniProt: O15389

  • Chr Location
    19q13.41; chr19:51610960-51645545 (-)  GRCh38
  • Human Ortholog
    SIGLEC8, sialic acid binding Ig like lectin 8
  • Synonyms
    SAF2, SIGLEC-8, SIGLEC8L
  • Links
    NCBI Gene ID: 27181
    neXtProt AC: NX_Q9NYZ4
    UniProt: Q9NYZ4

  • Chr Location
    19q13.41; chr19:51450847-51458456 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased lung inflammation in response to ovalbumin challenge with increased eosinophils, delayed eosinophil resolution and impaired eosinophil apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    7
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039013 Ensembl Gene Model | MGI Sequence Detail 8191 C57BL/6J ±  kb
    transcript ENSMUST00000122423 Ensembl | MGI Sequence Detail 2607 Not Applicable  
    polypeptide ENSMUSP00000113245 Ensembl | MGI Sequence Detail 569 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 3
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:72919 Angata T, et al., Cloning and characterization of a novel mouse Siglec, mSiglec-F: differential evolution of the mouse and human (CD33) Siglec-3-related gene clusters. J Biol Chem. 2001 Nov 30;276(48):45128-36
    • Latest
      J:330795 Wang X, et al., CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder. Cell Metab. 2022 Aug 2;34(8):1088-1103.e6
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory