Scgb3a2 MGI Mouse Gene Detail - MGI:2153470 - secretoglobin, family 3A, member 2

Symbol

Scgb3a2
Name

secretoglobin, family 3A, member 2
Synonyms

LuLeu1, UGRP1

Feature Type

protein coding gene
IDs

MGI:2153470
NCBI Gene: 117158
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr18:43897354-43900464 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 23.49 cM, cytoband C-D
Mapping Data

2 experiments

SNPs within 2kb

246 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2153470	protein coding gene	Chr18:43897346-43900464 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024388	protein coding gene	Chr18:42488045-42491156 (+)
A/J	MGP_AJ_G0024355	protein coding gene	Chr18:40991707-40994818 (+)
AKR/J	MGP_AKRJ_G0024324	protein coding gene	Chr18:42118631-42121742 (+)
BALB/cJ	MGP_BALBcJ_G0024355	protein coding gene	Chr18:41075753-41078864 (+)
C3H/HeJ	MGP_C3HHeJ_G0024122	protein coding gene	Chr18:42174257-42177368 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024799	protein coding gene	Chr18:43974916-43978026 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022235	protein coding gene	Chr18:40804800-40807921 (+)
CAST/EiJ	MGP_CASTEiJ_G0023596	protein coding gene	Chr18:42163557-42166668 (+)
CBA/J	MGP_CBAJ_G0024091	protein coding gene	Chr18:45203553-45206664 (+)
DBA/2J	MGP_DBA2J_G0024221	protein coding gene	Chr18:40587478-40590589 (+)
FVB/NJ	MGP_FVBNJ_G0024187	protein coding gene	Chr18:40185516-40188627 (+)
LP/J	MGP_LPJ_G0024305	protein coding gene	Chr18:42519679-42522790 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024218	protein coding gene	Chr18:46500338-46503448 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024846	protein coding gene	Chr18:42001980-42005090 (+)
PWK/PhJ	MGP_PWKPhJ_G0023340	protein coding gene	Chr18:40800613-40803730 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023145	protein coding gene	Chr18:42257136-42260263 (+)
WSB/EiJ	MGP_WSBEiJ_G0023659	protein coding gene	Chr18:41913394-41916505 (+)

Human Ortholog

SCGB3A2, secretoglobin family 3A member 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SCGB3A2, secretoglobin family 3A member 2
Synonyms

LU103, pnSP-1, PNSP1, UGRP1
Links

HGNC:18391

NCBI Gene ID: 117156

neXtProt AC: NX_Q96PL1

UniProt: Q96PL1
Chr Location

5q32; chr5:147870682-147882191 (+) GRCh38

MGI Vertebrate Homology

Scgb3a2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SCGB3A2
Gene Tree

Scgb3a2

Diseases

2 with human SCGB3A2 associations

				Human Disease	Mouse Models
				allergic rhinitis IDs allergic rhinitis DOID:4481 DOID:12089 DOID:14030 DOID:8241 DOID:8242 EFO:0003956 NCI:C34987 OMIM:607154 UMLS_CUI:C0002103
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 4 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

4
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit background sensitive lung inflammatory response to ovalbumin exposure.

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All GO Annotations

4
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

834
Tissues

59
cDNA Data

13
Literature Summary

31

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

43
RefSeq

6
UniProt

1
CCDS

CCDS29220.1, CCDS79640.1, CCDS79641.1

Ensembl

ENSMUSG00000038791 (Evidence)
NCBI Gene

117158

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038791	Ensembl Gene Model \| MGI Sequence Detail	3111	C57BL/6J	± kb
transcript	ENSMUST00000043803	Ensembl \| MGI Sequence Detail	842	Not Applicable
polypeptide	ENSMUSP00000038872	Ensembl \| MGI Sequence Detail	139	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031676 secretoglobin family 3A member 2

(term hierarchy)
InterPro Domains

IPR040301 Secretoglobin 3A

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All nucleic 25

Genomic 3

cDNA 13

Primer pair 8

Other 1

Microarray probesets 3

Summaries

All 59

Developmental Gene Expression 31

Gene Ontology 3

Phenotypes 9
Earliest

J:72388 Niimi T, et al., UGRP1, a Uteroglobin/Clara Cell Secretory Protein-Related Protein, Is a Novel Lung-Enriched Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor. Mol Endocrinol. 2001 Nov;15(11):2021-36
Latest

J:354192 He H, et al., PRDM3/16 regulate chromatin accessibility required for NKX2-1 mediated alveolar epithelial differentiation and function. Nat Commun. 2024 Sep 16;15(1):8112

TSS for Scgb3a2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150893	Chr18:43897382-43897398 (+)	36 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24