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Brwd1 Gene Detail
Summary
  • Symbol
    Brwd1
  • Name
    bromodomain and WD repeat domain containing 1
  • Synonyms
    5330419I02Rik, D530019K20Rik, G1-403-16, repro5, Wdr9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890651
    NCBI Gene: 93871
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:95793292-95883726 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 16, 56.77 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    347 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890651
protein coding gene Chr16:95793289-95883905 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023079
protein coding gene Chr16:97341885-97436978 (-)
A/J MGP_AJ_G0023047
protein coding gene Chr16:92721211-92817710 (-)
AKR/J MGP_AKRJ_G0023017
protein coding gene Chr16:95586761-95687551 (-)
BALB/cJ MGP_BALBcJ_G0023049
protein coding gene Chr16:93272804-93374422 (-)
C3H/HeJ MGP_C3HHeJ_G0022810
protein coding gene Chr16:96103534-96205076 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023496
protein coding gene Chr16:100427978-100525664 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020998
protein coding gene Chr16:90581736-90672800 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0022779
protein coding gene Chr16:104752391-104869310 (-)
DBA/2J MGP_DBA2J_G0022913
protein coding gene Chr16:92612686-92704167 (-)
FVB/NJ MGP_FVBNJ_G0022887
protein coding gene Chr16:91784584-91879663 (-)
LP/J MGP_LPJ_G0022983
protein coding gene Chr16:96967883-97070201 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022908
protein coding gene Chr16:108989619-109096842 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023514
protein coding gene Chr16:96118566-96218370 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0022380
protein coding gene Chr16:96376928-96483912 (-)



Homology
more
  • Human Ortholog
    BRWD1, bromodomain and WD repeat domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BRWD1, bromodomain and WD repeat domain containing 1
  • Synonyms
    C21orf107, CILD51, DCAF19, N143, WDR9, WRD9
  • Links
    NCBI Gene ID: 54014
    neXtProt AC: NX_Q9NSI6
    UniProt: Q9NSI6

  • Chr Location
    21q22.2; chr21:39184176-39321559 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human BRWD1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 3 alleles in 4 genetic backgrounds
    101 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous males and females are infertile. Spermiogenesis is impaired; males have low epididymal sperm concentration with low motility and abnormal sperm head morphology. Female oocytes commonly contain vacuoles and have low developmental competence to 2-cell and blastocyst stages.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022914 Ensembl Gene Model | MGI Sequence Detail 90435 C57BL/6J ±  kb
    transcript ENSMUST00000099502 Ensembl | MGI Sequence Detail 8547 Not Applicable  
    polypeptide ENSMUSP00000097101 Ensembl | MGI Sequence Detail 2304 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 1
      cDNA 30
      Primer pair 3
      Other 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1926107, MGI:2442152, MGI:3512790
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 9
      Diseases 6
      Gene Ontology 4
      Phenotypes 101
    • Earliest
      J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    10/22/2024
    MGI 6.24
    The Jackson Laboratory