Gps2 MGI Mouse Gene Detail - MGI:1891751 - G protein pathway suppressor 2

Symbol

Gps2
Name

G protein pathway suppressor 2

Feature Type

protein coding gene
IDs

MGI:1891751
NCBI Gene: 56310
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:69804714-69807417 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.92 cM
Mapping Data

1 experiment

SNPs within 2kb

24 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891751	protein coding gene	Chr11:69804714-69807882 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018568	protein coding gene	Chr11:70400825-70403529 (+)
A/J	MGP_AJ_G0018536	protein coding gene	Chr11:67735560-67738263 (+)
AKR/J	MGP_AKRJ_G0018505	protein coding gene	Chr11:69757917-69760620 (+)
BALB/cJ	MGP_BALBcJ_G0018508	protein coding gene	Chr11:68066909-68069612 (+)
C3H/HeJ	MGP_C3HHeJ_G0018321	protein coding gene	Chr11:69794477-69797180 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018959	protein coding gene	Chr11:72526432-72529135 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016604	protein coding gene	Chr11:64662198-64664918 (+)
CAST/EiJ	MGP_CASTEiJ_G0017876	protein coding gene	Chr11:70034717-70037424 (+)
CBA/J	MGP_CBAJ_G0029386	protein coding gene	Chr5:98078265-98080593 (-)
DBA/2J	MGP_DBA2J_G0018403	protein coding gene	Chr11:67321478-67324182 (+)
FVB/NJ	MGP_FVBNJ_G0018393	protein coding gene	Chr11:66962753-66965459 (+)
LP/J	MGP_LPJ_G0018473	protein coding gene	Chr11:70983588-70986292 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018416	protein coding gene	Chr11:76370318-76373021 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019001	protein coding gene	Chr11:70028363-70031066 (+)
PWK/PhJ	MGP_PWKPhJ_G0017650	protein coding gene	Chr11:67972209-67975262 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017440	protein coding gene	Chr11:69837765-69840471 (+)
WSB/EiJ	MGP_WSBEiJ_G0017930	protein coding gene	Chr11:69690891-69693595 (+)

Human Ortholog

GPS2, G protein pathway suppressor 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPS2, G protein pathway suppressor 2
Synonyms

AMF-1
Links

HGNC:4550

NCBI Gene ID: 2874

neXtProt AC: NX_Q13227

UniProt: Q13227
Chr Location

17p13.1; chr17:7311324-7315564 (-) GRCh38

MGI Vertebrate Homology

Gps2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GPS2
Gene Tree

Gps2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
1 images
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Targeted

4
Genomic Mutations

2 involving Gps2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available

Mice homozygous for a knock-out allele exhibit embryonic lethality during organogenesis.

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All GO Annotations

40
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

80

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gps2

ZFIN gps2

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All Sequences

46
RefSeq

6
UniProt

3
CCDS

CCDS24922.1

Ensembl

ENSMUSG00000023170 (Evidence)
NCBI Gene

56310

			Length	Strain/Species	Flank
genomic	ENSMUSG00000023170	Ensembl Gene Model \| MGI Sequence Detail	2704	C57BL/6J	± kb
transcript	ENSMUST00000072581	Ensembl \| MGI Sequence Detail	1311	Not Applicable
polypeptide	ENSMUSP00000072389	Ensembl \| MGI Sequence Detail	327	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000008203 G protein pathway suppressor 2

(term hierarchy)
InterPro Domains

IPR026094 G protein pathway suppressor 2

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All nucleic 80

cDNA 80

Microarray probesets 3

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MGI:2144211

Summaries

All 53

Gene Ontology 13

Phenotypes 20
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:305187 Huang Z, et al., The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages. Mol Cell. 2021 Mar 4;81(5):953-968.e9

TSS for Gps2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102552	Chr11:69804834-69804904 (+)	155 bp
Tssr102553	Chr11:69804978-69804989 (+)	270 bp
Tssr102554	Chr11:69805005-69805019 (+)	298 bp
Tssr102555	Chr11:69805062-69805092 (+)	363 bp
Tssr102556	Chr11:69805112-69805123 (+)	404 bp
Tssr102557	Chr11:69806866-69806881 (+)	2,160 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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