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Nop2 Gene Detail
Summary
  • Symbol
    Nop2
  • Name
    NOP2 nucleolar protein
  • Synonyms
    120kDa, Nol1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107891
    NCBI Gene: 110109
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:125108872-125121716 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 59.32 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    466 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107891
 protein coding gene Chr6:125108829-125121716 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031286
 protein coding gene Chr6:128461697-128475686 (+)
A/J MGP_AJ_G0031256
 protein coding gene Chr6:123616353-123629366 (+)
AKR/J MGP_AKRJ_G0031184
 protein coding gene Chr6:126992250-127005003 (+)
BALB/cJ MGP_BALBcJ_G0031264
 protein coding gene Chr6:123212413-123226419 (+)
C3H/HeJ MGP_C3HHeJ_G0030987
 protein coding gene Chr6:127053795-127066454 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031720
 protein coding gene Chr6:131839693-131853600 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0030368
 protein coding gene Chr6:127261282-127273984 (+)
CBA/J MGP_CBAJ_G0030948
 protein coding gene Chr6:136900690-136916439 (+)
DBA/2J MGP_DBA2J_G0031104
 protein coding gene Chr6:122547479-122560257 (+)
FVB/NJ MGP_FVBNJ_G0031054
 protein coding gene Chr6:121456770-121469501 (+)
LP/J MGP_LPJ_G0031184
 protein coding gene Chr6:128627679-128640340 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031092
 protein coding gene Chr6:140934730-140947632 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031755
 protein coding gene Chr6:126894097-126907024 (+)
PWK/PhJ MGP_PWKPhJ_G0030083
 protein coding gene Chr6:120790261-120803237 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029912
 protein coding gene Chr6:124969615-124982519 (+)
WSB/EiJ MGP_WSBEiJ_G0030453
 protein coding gene Chr6:127259107-127274973 (+)



Homology
more
  • Human Ortholog
    NOP2, NOP2 nucleolar protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NOP2, NOP2 nucleolar protein
  • Synonyms
    NOL1, NOP120, NSUN1, p120
  • Links
    NCBI Gene ID: 4839
    neXtProt AC: NX_P46087
    UniProt: P46087

  • Chr Location
    12p13.31; chr12:6556863-6568691 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit complete prenatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    896
  • Tissues
    63
  • cDNA Data
    105
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038279 Ensembl Gene Model | MGI Sequence Detail 12845 C57BL/6J ±  kb
transcript ENSMUST00000044200 Ensembl | MGI Sequence Detail 2597 Not Applicable  
polypeptide ENSMUSP00000047123 Ensembl | MGI Sequence Detail 794 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000029647 probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase
    (term hierarchy)
  • EC
    2.1.1.-
  • InterPro Domains
    IPR018314 Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site
    IPR011023 Nop2p
    IPR012586 P120R repeat
    IPR023267 RNA (C5-cytosine) methyltransferase
    IPR023273 RNA (C5-cytosine) methyltransferase, NOP2
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
    IPR049560 SAM-dependent methyltransferase RsmB-F/NOP2-type, catalytic core
    IPR001678 SAM-dependent methyltransferase RsmB-F/NOP2-type domain
  • GlyGen
    Q922K7 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 108
    cDNA 105
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36469
References
more
  • Summaries
    All 41
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory