Riok1 MGI Mouse Gene Detail - MGI:1918590

Symbol

Riok1
Name

RIO kinase 1
Synonyms

3110046C13Rik, 5430416A05Rik

Feature Type

protein coding gene
IDs

MGI:1918590
NCBI Gene: 71340
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr13:38220971-38245409 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 17.91 cM
Mapping Data

2 experiments

SNPs within 2kb

924 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918590	protein coding gene	Chr13:38220965-38245409 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020469	protein coding gene	Chr13:36353180-36377589 (+)
A/J	MGP_AJ_G0020423	protein coding gene	Chr13:35209216-35233727 (+)
AKR/J	MGP_AKRJ_G0020401	protein coding gene	Chr13:36140750-36165551 (+)
BALB/cJ	MGP_BALBcJ_G0020419	protein coding gene	Chr13:35309234-35333618 (+)
C3H/HeJ	MGP_C3HHeJ_G0020218	protein coding gene	Chr13:35966117-35991488 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020852	protein coding gene	Chr13:37534428-37559410 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018439	protein coding gene	Chr13:33387081-33412240 (+)
CAST/EiJ	MGP_CASTEiJ_G0019733	protein coding gene	Chr13:35733757-35762984 (+)
CBA/J	MGP_CBAJ_G0020179	protein coding gene	Chr13:39135763-39160206 (+)
DBA/2J	MGP_DBA2J_G0020301	protein coding gene	Chr13:34727178-34751621 (+)
FVB/NJ	MGP_FVBNJ_G0020280	protein coding gene	Chr13:34266411-34291056 (+)
LP/J	MGP_LPJ_G0020376	protein coding gene	Chr13:36594132-36623677 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020310	protein coding gene	Chr13:39238682-39263117 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020895	protein coding gene	Chr13:35706944-35731388 (+)
PWK/PhJ	MGP_PWKPhJ_G0019488	protein coding gene	Chr13:34852981-34877959 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019319	protein coding gene	Chr13:34370896-34416683 (+)
WSB/EiJ	MGP_WSBEiJ_G0019795	protein coding gene	Chr13:36052418-36077438 (+)

Human Ortholog

RIOK1, RIO kinase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RIOK1, RIO kinase 1
Synonyms

AD034, bA288G3.1, RIO1, RRP10
Links

HGNC:18656

NCBI Gene ID: 83732

neXtProt AC: NX_Q9BRS2

UniProt: Q9BRS2
Chr Location

6p24.3; chr6:7389793-7418037 (+) GRCh38

MGI Vertebrate Homology

Riok1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RIOK1
Protein SuperFamily

Ser/Thr_PK_RIO1
Gene Tree

Riok1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
1 images
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

3
Genomic Mutations

1 involving Riok1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available

Mice homozygous for a knock-out allele show normal blastocyst formation but exhibit complete embryonic lethality prior to organogenesis.

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All GO Annotations

40
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

13
cDNA Data

72
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase riok1

ZFIN riok1

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All Sequences

65
RefSeq

6
UniProt

5
CCDS

CCDS26461.1

Ensembl

ENSMUSG00000021428 (Evidence)
NCBI Gene

71340

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021428	Ensembl Gene Model \| MGI Sequence Detail	24439	C57BL/6J	± kb
transcript	ENSMUST00000021866	Ensembl \| MGI Sequence Detail	2738	Not Applicable
polypeptide	ENSMUSP00000021866	Ensembl \| MGI Sequence Detail	567	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000014019 serine/threonine-protein kinase RIO1

(term hierarchy)
EC

2.7.11.1, 3.6.3.-
InterPro Domains

IPR011009 Protein kinase-like domain superfamily

IPR000687 RIO kinase

IPR018935 RIO kinase, conserved site

IPR051272 RIO-type Ser/Thr kinase

IPR017407 Serine/threonine-protein kinase Rio1

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All nucleic 73

cDNA 72

Primer pair 1

Microarray probesets 5

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MGI:1920472, MGI:2145325

Summaries

All 45

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 14
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Riok1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119342	Chr13:38221211-38221286 (+)	278 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24