Blvrb MGI Mouse Gene Detail - MGI:2385271

Symbol

Blvrb
Name

biliverdin reductase B
Synonyms

MGC:11726, MGC:27866

Feature Type

protein coding gene
IDs

MGI:2385271
NCBI Gene: 233016
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr7:27147403-27165406 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 15.90 cM
Mapping Data

1 experiment

SNPs within 2kb

639 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385271	protein coding gene	Chr7:27147403-27165569 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031911	protein coding gene	Chr7:26101670-26122716 (+)
A/J	MGP_AJ_G0031890	protein coding gene	Chr7:25471241-25490481 (+)
AKR/J	MGP_AKRJ_G0031820	protein coding gene	Chr7:26150875-26171965 (+)
BALB/cJ	MGP_BALBcJ_G0031895	protein coding gene	Chr7:25688533-25707179 (+)
C3H/HeJ	MGP_C3HHeJ_G0031617	protein coding gene	Chr7:26527176-26546186 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032360	protein coding gene	Chr7:26959263-26978751 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029412	protein coding gene	Chr7:26703756-26722563 (+)
CAST/EiJ	MGP_CASTEiJ_G0030952	protein coding gene	Chr7:19837038-19855955 (+)
CBA/J	MGP_CBAJ_G0031582	protein coding gene	Chr7:28153450-28171618 (+)
DBA/2J	MGP_DBA2J_G0031734	protein coding gene	Chr7:25271353-25289857 (+)
FVB/NJ	MGP_FVBNJ_G0031690	protein coding gene	Chr7:25365697-25384468 (+)
LP/J	MGP_LPJ_G0031814	protein coding gene	Chr7:26435890-26455696 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031725	protein coding gene	Chr7:27729909-27750146 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032391	protein coding gene	Chr7:25685092-25705703 (+)
PWK/PhJ	MGP_PWKPhJ_G0030676	protein coding gene	Chr7:20306517-20326070 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030510	protein coding gene	Chr7:16675029-16698848 (+)
WSB/EiJ	MGP_WSBEiJ_G0031060	protein coding gene	Chr7:25971539-25989536 (+)

Human Ortholog

BLVRB, biliverdin reductase B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BLVRB, biliverdin reductase B
Synonyms

BVRB, FLR, HEL-S-10, SDR43U1
Links

HGNC:1063

NCBI Gene ID: 645

neXtProt AC: NX_P30043

UniProt: P30043
Chr Location

19q13.2; chr19:40447765-40465764 (-) GRCh38

MGI Vertebrate Homology

Blvrb stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BLVRB
Gene Tree

Blvrb

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Gene trapped

3
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

25
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

823
Tissues

95
cDNA Data

68
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase blvrb

ZFIN blvrb

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All Sequences

48
RefSeq

4
UniProt

6
CCDS

CCDS39848.1, CCDS71922.1

Ensembl

ENSMUSG00000040466 (Evidence)
NCBI Gene

233016

			Length	Strain/Species	Flank
genomic	233016	NCBI Gene Model \| MGI Sequence Detail	18004	C57BL/6J	± kb
transcript	NM_144923	RefSeq \| MGI Sequence Detail	865	C57BL/6
polypeptide	Q923D2	UniProt \| EBI \| MGI Sequence Detail	206	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000004766 flavin reductase

(term hierarchy)
EC

1.3.1.-, 1.5.1.30, 2.6.99.-
InterPro Domains

IPR016040 NAD(P)-binding domain

IPR036291 NAD(P)-binding domain superfamily

IPR051606 Polyketide Oxidoreductase-like
GlyGen

Q923D2 1 site, 1 O-linked glycan (1 site)

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All nucleic 68

cDNA 68

Microarray probesets 5

Summaries

All 36

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 10
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Blvrb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65266	Chr7:27147420-27147471 (+)	43 bp
Tssr65267	Chr7:27147476-27147494 (+)	82 bp
Tssr65268	Chr7:27151842-27151894 (+)	4,465 bp
Tssr65269	Chr7:27155427-27155431 (+)	8,026 bp
Tssr65270	Chr7:27158749-27158769 (+)	11,356 bp
Tssr65271	Chr7:27158771-27158795 (+)	11,380 bp
Tssr65272	Chr7:27158796-27158816 (+)	11,403 bp
Tssr65273	Chr7:27160865-27160868 (+)	13,464 bp
Tssr65274	Chr7:27161118-27161128 (+)	13,720 bp
Tssr65275	Chr7:27161982-27162000 (+)	14,588 bp
Tssr65276	Chr7:27162004-27162029 (+)	14,614 bp
Tssr65277	Chr7:27162032-27162047 (+)	14,637 bp
Tssr65278	Chr7:27162080-27162094 (+)	14,684 bp
Tssr65279	Chr7:27165140-27165157 (+)	17,746 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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