Trpm7 MGI Mouse Gene Detail - MGI:1929996 - transient receptor potential cation channel, subfamily M, member 7

Symbol

Trpm7
Name

transient receptor potential cation channel, subfamily M, member 7
Synonyms

2310022G15Rik, 4833414K03Rik, 5033407O22Rik, CHAK, CHAK1, Ltpr7, LTRPC7, TRP-PLIK

Feature Type

protein coding gene
IDs

MGI:1929996
NCBI Gene: 58800
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:126633485-126718150 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 61.76 cM, cytoband F2
Mapping Data

2 experiments

SNPs within 2kb

1591 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929996	protein coding gene	Chr2:126633478-126718181 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026445	protein coding gene	Chr2:130030576-130115795 (-)
A/J	MGP_AJ_G0026409	protein coding gene	Chr2:124762005-124847486 (-)
AKR/J	MGP_AKRJ_G0026384	protein coding gene	Chr2:128325252-128410932 (-)
BALB/cJ	MGP_BALBcJ_G0026421	protein coding gene	Chr2:125034464-125119483 (-)
C3H/HeJ	MGP_C3HHeJ_G0026164	protein coding gene	Chr2:128830852-128919999 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026866	protein coding gene	Chr2:134159298-134247115 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024243	protein coding gene	Chr2:119479208-119564556 (-)
CAST/EiJ	MGP_CASTEiJ_G0025625	protein coding gene	Chr2:129045793-129133082 (-)
CBA/J	MGP_CBAJ_G0026144	protein coding gene	Chr2:139082973-139176385 (-)
DBA/2J	MGP_DBA2J_G0026278	protein coding gene	Chr2:124175788-124261731 (-)
FVB/NJ	MGP_FVBNJ_G0026242	protein coding gene	Chr2:122824331-122911595 (-)
LP/J	MGP_LPJ_G0026383	protein coding gene	Chr2:130280146-130366565 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026262	protein coding gene	Chr2:143141554-143238617 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026921	protein coding gene	Chr2:128361744-128450424 (-)
PWK/PhJ	MGP_PWKPhJ_G0025361	protein coding gene	Chr2:123714494-123803217 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025163	protein coding gene	Chr2:127433259-127521423 (-)
WSB/EiJ	MGP_WSBEiJ_G0025699	protein coding gene	Chr2:129242612-129332555 (-)

Human Ortholog

TRPM7, transient receptor potential cation channel subfamily M member 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRPM7, transient receptor potential cation channel subfamily M member 7
Synonyms

ALSPDC, CHAK, CHAK1, LTrpC-7, LTRPC7, TRP-PLIK
Links

HGNC:17994

NCBI Gene ID: 54822

neXtProt AC: NX_Q96QT4

UniProt: Q96QT4
Chr Location

15q21.2; chr15:50552473-50686797 (-) GRCh38

MGI Vertebrate Homology

Trpm7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TRPM7
Gene Tree

Trpm7

Diseases

1 with human TRPM7 associations

				Human Disease	Mouse Models
				amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 IDs amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 DOID:0111246 MESH:D000690 OMIM:105500 ORDO:90020 UMLS_CUI:C0543859

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

54 phenotypes from 6 alleles in 8 genetic backgrounds
4 images
54 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

11
Radiation induced

1
Targeted

13
Genomic Mutations

2 involving Trpm7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

102 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display embryonic lehality. Mice with conditional deletion in developing thymocytes display a block in thymopoiesis. Mice homozygous for a kinase deleted allele exhibit prenatal lethality. Mice heterozygous for this allele exhibit altered magnesium homeostasis.

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All GO Annotations

49
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

794
Tissues

48
cDNA Data

12
Literature Summary

15

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase trpm7

ZFIN trpm7

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All Sequences

66
RefSeq

10
UniProt

4
CCDS

CCDS16689.1, CCDS50700.1

Ensembl

ENSMUSG00000027365 (Evidence)
NCBI Gene

58800

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027365	Ensembl Gene Model \| MGI Sequence Detail	84666	C57BL/6J	± kb
transcript	ENSMUST00000103224	Ensembl \| MGI Sequence Detail	7107	Not Applicable
polypeptide	ENSMUSP00000099513	Ensembl \| MGI Sequence Detail	1863	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000016703 transient receptor potential cation channel subfamily M member 7

(term hierarchy)
PDB

1IA9, 1IAH, 1IAJ, 5ZX5, 6BWD, 6BWF, 8SI2, 8SI3, 8SI4, 8SI5, 8SI6, 8SI7, 8SI8, 8SIA, 8SIB, 8W2L
EC

2.7.11.1
InterPro Domains

IPR051852 Alpha-type Protein Kinase

IPR004166 Alpha-type protein kinase, alpha-kinase domain

IPR005821 Ion transport domain

IPR011009 Protein kinase-like domain superfamily

IPR050927 Transient receptor potential cation channel M

IPR029601 Transient receptor potential cation channel subfamily M member 7, alpha-kinase domain

IPR041491 TRPM, SLOG domain

IPR032415 TRPM, tetramerisation domain

IPR037162 TRPM, tetramerisation domain superfamily

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All nucleic 17

cDNA 14

Primer pair 3

Microarray probesets 6

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MGI:1921848, MGI:1923209, MGI:1924250

Summaries

All 118

Developmental Gene Expression 15

Gene Ontology 15

Phenotypes 54
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Trpm7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr26071	Chr2:126718129-126718187 (-)	-8 bp
Tssr26070	Chr2:126718099-126718125 (-)	38 bp
Tssr26069	Chr2:126718069-126718091 (-)	70 bp
Tssr26068	Chr2:126705190-126705194 (-)	12,958 bp
Tssr26067	Chr2:126652158-126652161 (-)	65,990 bp
Tssr26066	Chr2:126639730-126639746 (-)	78,412 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24