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Camk2g Gene Detail
Summary
  • Symbol
    Camk2g
  • Name
    calcium/calmodulin-dependent protein kinase II gamma
  • Synonyms
    5930429P18Rik, Ca2+/calmodulin-dependent protein kinase II, Camkg, CaMK II
  • Feature Type
    protein coding gene
  • IDs
    MGI:88259
    NCBI Gene: 12325
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:20784943-20844156 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 11.53 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1071 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88259
 protein coding gene Chr14:20784943-20844225 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021047
 protein coding gene Chr14:13503494-13570924 (-)
A/J MGP_AJ_G0020996
 protein coding gene Chr14:13191070-13250389 (-)
AKR/J MGP_AKRJ_G0020973
 protein coding gene Chr14:13717601-13776661 (-)
BALB/cJ MGP_BALBcJ_G0020999
 protein coding gene Chr14:13296257-13359466 (-)
C3H/HeJ MGP_C3HHeJ_G0020783
 protein coding gene Chr14:13656103-13716932 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021432
 protein coding gene Chr14:14002623-14062364 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019000
 protein coding gene Chr14:13507589-13567066 (-)
CAST/EiJ MGP_CASTEiJ_G0020307
 protein coding gene Chr14:13420879-13484262 (-)
CBA/J MGP_CBAJ_G0020749
 protein coding gene Chr14:14714157-14775238 (-)
DBA/2J MGP_DBA2J_G0020872
 protein coding gene Chr14:13015474-13076104 (-)
FVB/NJ MGP_FVBNJ_G0020855
 protein coding gene Chr14:12908566-12972540 (-)
LP/J MGP_LPJ_G0020948
 protein coding gene Chr14:13729333-13791073 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020881
 protein coding gene Chr14:14490052-14549779 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021465
 protein coding gene Chr14:13508580-13584430 (-)
PWK/PhJ MGP_PWKPhJ_G0020056
 protein coding gene Chr14:12585960-12646016 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019878
 protein coding gene Chr14:13303171-13362293 (-)
WSB/EiJ MGP_WSBEiJ_G0020363
 protein coding gene Chr14:13491097-13555447 (-)



Homology
more
  • Human Ortholog
    CAMK2G, calcium/calmodulin dependent protein kinase II gamma
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CAMK2G, calcium/calmodulin dependent protein kinase II gamma
  • Synonyms
    CAMK, CAMKG, CAMK-II, MRD59
  • Links
    NCBI Gene ID: 818
    neXtProt AC: NX_Q13555
    UniProt: Q13555

  • Chr Location
    10q22.2; chr10:73812501-73874591 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CAMK2G associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit female infertility and decreased sensitivity of macrophages to ER stress-induced apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    942
  • Tissues
    151
  • cDNA Data
    17
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021820 Ensembl Gene Model | MGI Sequence Detail 59214 C57BL/6J ±  kb
    transcript ENSMUST00000226630 Ensembl | MGI Sequence Detail 1937 Not Applicable  
    polypeptide ENSMUSP00000154158 Ensembl | MGI Sequence Detail 565 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000003202 calcium/calmodulin-dependent protein kinase type II subunit gamma
      (term hierarchy)
    • EC
      2.7.11.17
    • InterPro Domains
      IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domain
      IPR032710 NTF2-like domain superfamily
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
    • GlyGen
      Q923T9 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 1
      cDNA 17
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1746, MGI:2442091
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 18
      Gene Ontology 12
      Phenotypes 32
    • Earliest
      J:16757 Li X, et al., Localization of the CAMKG gene encoding gamma isoforms of multifunctional calcium/calmodulin-dependent protein kinase (CaM kinase) to human chromosome 10 band q22 and mouse chromosome 14. Cytogenet Cell Genet. 1994;66(2):113-6
    • Latest
      J:347984 Naillat F, et al., Calcium signaling induces partial EMT and renal fibrosis in a Wnt4(mCherry) knock-in mouse model. Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21;1870(5):167180
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory