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Rad51c Gene Detail
Summary
  • Symbol
    Rad51c
  • Name
    RAD51 paralog C
  • Synonyms
    Rad51l2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2150020
    NCBI Gene: 114714
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:87267471-87295780 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 52.08 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    69 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2150020
 protein coding gene Chr11:87267471-87295780 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018903
 protein coding gene Chr11:88971230-89009452 (-)
A/J MGP_AJ_G0018870
 protein coding gene Chr11:85549597-85578067 (-)
AKR/J MGP_AKRJ_G0018840
 protein coding gene Chr11:88109877-88143074 (-)
BALB/cJ MGP_BALBcJ_G0018843
 protein coding gene Chr11:85949202-85979631 (-)
C3H/HeJ MGP_C3HHeJ_G0018657
 protein coding gene Chr11:88129740-88159851 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019295
 protein coding gene Chr11:91653512-91690291 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016928
 protein coding gene Chr11:82579287-82609292 (-)
CAST/EiJ MGP_CASTEiJ_G0018212
 protein coding gene Chr11:88838308-88868182 (-)
CBA/J MGP_CBAJ_G0018628
 protein coding gene Chr11:95513208-95550031 (-)
DBA/2J MGP_DBA2J_G0018736
 protein coding gene Chr11:85109350-85138083 (-)
FVB/NJ MGP_FVBNJ_G0018725
 protein coding gene Chr11:84615063-84643581 (-)
LP/J MGP_LPJ_G0018806
 protein coding gene Chr11:89471957-89501870 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018752
 protein coding gene Chr11:95570910-95604681 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019335
 protein coding gene Chr11:88343563-88373414 (-)
PWK/PhJ MGP_PWKPhJ_G0017982
 protein coding gene Chr11:85930926-85959563 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017774
 protein coding gene Chr11:87913449-87948324 (-)
WSB/EiJ MGP_WSBEiJ_G0018263
 protein coding gene Chr11:88225377-88265527 (-)



Homology
more
  • Human Ortholog
    RAD51C, RAD51 paralog C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAD51C, RAD51 paralog C
  • Synonyms
    BROVCA3, FANCO, R51H3, RAD51L2
  • Links
    NCBI Gene ID: 5889
    neXtProt AC: NX_O43502
    UniProt: O43502

  • Chr Location
    17q22; chr17:58692573-58735611 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human RAD51C associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 4 alleles in 4 genetic backgrounds
    2 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display embryonic lethality. Mice carrying a null and a hypomorphic allele have partial penetrance of male and female infertility due to defects in meiosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    12
  • cDNA Data
    14
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 114714 NCBI Gene Model | MGI Sequence Detail 28310 C57BL/6J ±  kb
    transcript NM_001291440 RefSeq | MGI Sequence Detail 4084 ZRU/MplStud  
    polypeptide Q924H5 UniProt | EBI | MGI Sequence Detail 366 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000013675 DNA repair protein RAD51 homolog 3
      (term hierarchy)
    • InterPro Domains
      IPR013632 DNA recombination and repair protein Rad51-like, C-terminal
      IPR016467 DNA recombination and repair protein, RecA-like
      IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain
      IPR010995 DNA repair Rad51/transcription factor NusA, alpha-helical
      IPR052093 Homologous Recombination Repair Mediator
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 2
      cDNA 15

      Microarray probesets 4
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 19
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:334068 Tomaszowski KH, et al., Hypomorphic Brca2 and Rad51c double mutant mice display Fanconi anemia, cancer and polygenic replication stress. Nat Commun. 2023 Mar 11;14(1):1333
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory