Taldo1 MGI Mouse Gene Detail - MGI:1274789

Symbol

Taldo1
Name

transaldolase 1

Feature Type

protein coding gene
IDs

MGI:1274789
NCBI Gene: 21351
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr7:140972112-140982881 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 86.73 cM, cytoband F3-F4
Mapping Data

2 experiments

SNPs within 2kb

465 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1274789	protein coding gene	Chr7:140972073-140982889 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033226	protein coding gene	Chr7:146578832-146590245 (+)
A/J	MGP_AJ_G0033208	protein coding gene	Chr7:142385548-142396283 (+)
AKR/J	MGP_AKRJ_G0033140	protein coding gene	Chr7:146318989-146332295 (+)
BALB/cJ	MGP_BALBcJ_G0033209	protein coding gene	Chr7:142131039-142142379 (+)
C3H/HeJ	MGP_C3HHeJ_G0032923	protein coding gene	Chr7:146076639-146087511 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033720	protein coding gene	Chr7:151930208-151942087 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030693	protein coding gene	Chr7:143600678-143611074 (+)
CAST/EiJ	MGP_CASTEiJ_G0032253	protein coding gene	Chr7:138384450-138396842 (+)
CBA/J	MGP_CBAJ_G0032895	protein coding gene	Chr7:157087145-157097943 (+)
DBA/2J	MGP_DBA2J_G0033047	protein coding gene	Chr7:140333739-140345297 (+)
FVB/NJ	MGP_FVBNJ_G0033000	protein coding gene	Chr7:140248399-140260478 (+)
LP/J	MGP_LPJ_G0033142	protein coding gene	Chr7:148075561-148086996 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033033	protein coding gene	Chr7:157725233-157736746 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033740	protein coding gene	Chr7:145292242-145303677 (+)
PWK/PhJ	MGP_PWKPhJ_G0031957	protein coding gene	Chr7:133615175-133627041 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031804	protein coding gene	Chr7:132116569-132136269 (+)
WSB/EiJ	MGP_WSBEiJ_G0032364	protein coding gene	Chr7:146240845-146252745 (+)

Human Ortholog

TALDO1, transaldolase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TALDO1, transaldolase 1
Synonyms

TAL, TALDOR, TAL-H, TALH
Links

HGNC:11559

NCBI Gene ID: 6888

neXtProt AC: NX_P37837

UniProt: P37837
Chr Location

11p15.5; chr11:747415-765012 (+) GRCh38

MGI Vertebrate Homology

Taldo1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TALDO1
Gene Tree

Taldo1

Diseases

1 with human TALDO1 associations

				Human Disease	Mouse Models
				carbohydrate metabolic disorder IDs carbohydrate metabolic disorder DOID:2978 DOID:9434 ICD9CM:271.8 MESH:D002239 NCI:C97089 ORDO:79161 UMLS_CUI:C0007001 UMLS_CUI:C0149670

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

2
Gene trapped

3
Radiation induced

1
Targeted

3
Genomic Mutations

1 involving Taldo1
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in male infertility due to defective sperm motility because of functional and structural defects of mitochondria in the sperm. Heterozygous mice show reduced male fertility.

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All GO Annotations

24
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

806
Tissues

97
cDNA Data

400
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase taldo1

ZFIN taldo1

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All Sequences

43
RefSeq

2
UniProt

2
CCDS

CCDS22011.1

Ensembl

ENSMUSG00000025503 (Evidence)
NCBI Gene

21351

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025503	Ensembl Gene Model \| MGI Sequence Detail	10770	C57BL/6J	± kb
transcript	ENSMUST00000211654	Ensembl \| MGI Sequence Detail	1362	Not Applicable
polypeptide	ENSMUSP00000147332	Ensembl \| MGI Sequence Detail	382	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016045 transaldolase

(term hierarchy)
PDB

2CWN, 2E1D
EC

2.2.1.2
InterPro Domains

IPR013785 Aldolase-type TIM barrel

IPR018225 Transaldolase, active site

IPR001585 Transaldolase/Fructose-6-phosphate aldolase

IPR004730 Transaldolase type 1
GlyGen

Q93092 1 site, 1 O-linked glycan (1 site)

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All nucleic 401

cDNA 400

Primer pair 1

Microarray probesets 3

Summaries

All 41

Developmental Gene Expression 3

Gene Ontology 10

Phenotypes 12
Earliest

J:322975 HIATT HH, Glycogen formation via the pentose phosphate pathway in mice in vivo. J Biol Chem. 1957 Feb;224(2):851-9
Latest

J:338387 Oaks Z, et al., Cytosolic aldose metabolism contributes to progression from cirrhosis to hepatocarcinogenesis. Nat Metab. 2023 Jan;5(1):41-60

TSS for Taldo1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr69956	Chr7:140972077-140972126 (+)	-10 bp
Tssr69957	Chr7:140972129-140972140 (+)	23 bp
Tssr69958	Chr7:140973096-140973099 (+)	986 bp
Tssr69959	Chr7:140975502-140975515 (+)	3,397 bp
Tssr69960	Chr7:140981781-140981795 (+)	9,676 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24