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Gatb Gene Detail
Summary
  • Symbol
    Gatb
  • Name
    glutamyl-tRNA amidotransferase subunit B
  • Synonyms
    9430026F02Rik, Pet112, Pet112l
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442496
    NCBI Gene: 229487
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:85481426-85562929 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 37.83 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1729 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442496
 protein coding gene Chr3:85481409-85562945 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027348
 protein coding gene Chr3:85580854-85661414 (+)
A/J MGP_AJ_G0027312
 protein coding gene Chr3:82698543-82773707 (+)
AKR/J MGP_AKRJ_G0027278
 protein coding gene Chr3:84655619-84738406 (+)
BALB/cJ MGP_BALBcJ_G0027321
 protein coding gene Chr3:82775524-82851006 (+)
C3H/HeJ MGP_C3HHeJ_G0027065
 protein coding gene Chr3:84971257-85051324 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027767
 protein coding gene Chr3:88759121-88844667 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025120
 protein coding gene Chr3:78345739-78421848 (+)
CAST/EiJ MGP_CASTEiJ_G0026512
 protein coding gene Chr3:85164125-85245619 (+)
CBA/J MGP_CBAJ_G0027040
 protein coding gene Chr3:91728676-91812272 (+)
DBA/2J MGP_DBA2J_G0027176
 protein coding gene Chr3:82195385-82270137 (+)
FVB/NJ MGP_FVBNJ_G0027144
 protein coding gene Chr3:80488254-80571698 (+)
LP/J MGP_LPJ_G0027284
 protein coding gene Chr3:86521995-86600832 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027163
 protein coding gene Chr3:97999466-98080581 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027825
 protein coding gene Chr3:84453875-84533624 (+)
PWK/PhJ MGP_PWKPhJ_G0026246
 protein coding gene Chr3:81991012-82066078 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026062
 protein coding gene Chr3:83605918-83694560 (+)
WSB/EiJ MGP_WSBEiJ_G0026590
 protein coding gene Chr3:84831940-84908652 (+)



Homology
more
  • Human Ortholog
    GATB, glutamyl-tRNA amidotransferase subunit B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GATB, glutamyl-tRNA amidotransferase subunit B
  • Synonyms
    COXPD41, HSPC199, PET112, PET112L
  • Links
    NCBI Gene ID: 5188
    neXtProt AC: NX_O75879
    UniProt: O75879

  • Chr Location
    4q31.3; chr4:151670504-151761007 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GATB associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving Gatb
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    22 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    11
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028085 Ensembl Gene Model | MGI Sequence Detail 81504 C57BL/6J ±  kb
transcript ENSMUST00000127348 Ensembl | MGI Sequence Detail 3469 Not Applicable  
polypeptide ENSMUSP00000119949 Ensembl | MGI Sequence Detail 557 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000029504 glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial
    (term hierarchy)
  • EC
    6.3.5.-
  • InterPro Domains
    IPR018027 Asn/Gln amidotransferase
    IPR003789 Aspartyl/glutamyl-tRNA amidotransferase subunit B-like
    IPR023168 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C-terminal, domain 2
    IPR004413 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B
    IPR017959 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, subunit B /E
    IPR006075 Aspartyl/Glutamyl-tRNA(Gln) amidotransferase, subunit B/E, catalytic
    IPR014746 Glutamine synthetase/guanido kinase, catalytic domain
    IPR017958 Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 4
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory