Nxf1 MGI Mouse Gene Detail - MGI:1858330 - nuclear RNA export factor 1

Symbol

Nxf1
Name

nuclear RNA export factor 1
Synonyms

Mex67, Mvb1, TAP, Tip associated protein

Feature Type

protein coding gene
IDs

MGI:1858330
NCBI Gene: 53319
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr19:8734467-8748274 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 5.50 cM, cytoband A
Mapping Data

4 experiments

SNPs within 2kb

277 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858330	protein coding gene	Chr19:8734437-8748286 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024807	protein coding gene	Chr19:6030819-6048883 (+)
A/J	MGP_AJ_G0024775	protein coding gene	Chr19:5709049-5724473 (+)
AKR/J	MGP_AKRJ_G0024750	protein coding gene	Chr19:5797380-5812618 (+)
BALB/cJ	MGP_BALBcJ_G0024775	protein coding gene	Chr19:5813282-5829207 (+)
C3H/HeJ	MGP_C3HHeJ_G0024541	protein coding gene	Chr19:5878230-5893617 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025222	protein coding gene	Chr19:6149992-6170134 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022651	protein coding gene	Chr19:5952928-5969090 (+)
CAST/EiJ	MGP_CASTEiJ_G0024014	protein coding gene	Chr19:5526642-5544952 (+)
CBA/J	MGP_CBAJ_G0024515	protein coding gene	Chr19:6270148-6288623 (+)
DBA/2J	MGP_DBA2J_G0024642	protein coding gene	Chr19:5539690-5556003 (+)
FVB/NJ	MGP_FVBNJ_G0024609	protein coding gene	Chr19:5614916-5630133 (+)
LP/J	MGP_LPJ_G0024729	protein coding gene	Chr19:5919959-5937426 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024636	protein coding gene	Chr19:6135623-6153198 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025271	protein coding gene	Chr19:5842181-5857598 (+)
PWK/PhJ	MGP_PWKPhJ_G0023759	protein coding gene	Chr19:5205352-5224426 (+)
SPRET/EiJ	no annotation
WSB/EiJ	MGP_WSBEiJ_G0024076	protein coding gene	Chr19:5809229-5825311 (+)

Human Ortholog

NXF1, nuclear RNA export factor 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NXF1, nuclear RNA export factor 1
Synonyms

MEX67, TAP
Links

HGNC:8071

NCBI Gene ID: 10482

neXtProt AC: NX_Q9UBU9

UniProt: Q9UBU9
Chr Location

11q12.3; chr11:62792123-62806302 (-) GRCh38

MGI Vertebrate Homology

Nxf1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NXF1
Gene Tree

Nxf1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
14 phenotypes from multigenic genotypes
10 phenotype references

All Mutations and Alleles

14
Endonuclease-mediated

2
Gene trapped

9
Spontaneous

1
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

36 strains or lines available

Mice homozygous for some alleles are able to suppress defects caused by retrovirus insertion mutations.

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All GO Annotations

30
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

739
Tissues

33
cDNA Data

11
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nxf1

ZFIN nxf1b

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All Sequences

59
RefSeq

4
UniProt

6
CCDS

CCDS29543.1, CCDS70930.1

Ensembl

ENSMUSG00000010097 (Evidence)
NCBI Gene

53319

			Length	Strain/Species	Flank
genomic	53319	NCBI Gene Model \| MGI Sequence Detail	13808	C57BL/6J	± kb
transcript	NM_001276704	RefSeq \| MGI Sequence Detail	4035	ZRU/MplStud
polypeptide	Q99JX7	UniProt \| EBI \| MGI Sequence Detail	618	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000011535 nuclear RNA export factor 1

(term hierarchy)
InterPro Domains

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR032710 NTF2-like domain superfamily

IPR030217 Nuclear RNA export factor

IPR015245 Nuclear RNA export factor Tap, RNA-binding domain

IPR002075 Nuclear transport factor 2 domain

IPR018222 Nuclear transport factor 2, eukaryote

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR005637 TAP C-terminal (TAP-C) domain

IPR009060 UBA-like superfamily
GlyGen

Q99JX7 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 16

cDNA 14

Primer pair 2

Microarray probesets 3

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MGI:1194888

Summaries

All 47

Developmental Gene Expression 3

Gene Ontology 10

Phenotypes 10
Earliest

J:40754 Hamilton BA, et al., The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression. Neuron. 1997 May;18(5):711-22
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Nxf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154814	Chr19:8734087-8734108 (+)	-369 bp
Tssr154815	Chr19:8734443-8734457 (+)	-17 bp
Tssr154816	Chr19:8734463-8734490 (+)	10 bp
Tssr154817	Chr19:8734503-8734519 (+)	44 bp
Tssr154818	Chr19:8734778-8734811 (+)	328 bp
Tssr154819	Chr19:8742394-8742398 (+)	7,929 bp
Tssr154820	Chr19:8744078-8744091 (+)	9,618 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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