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Arfgap2 Gene Detail
Summary
  • Symbol
    Arfgap2
  • Name
    ARF GTPase activating protein 2
  • Synonyms
    2310032E02Rik, Zfp289
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924288
    NCBI Gene: 77038
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:91095319-91107276 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 50.62 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    293 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924288
 protein coding gene Chr2:91095319-91107716 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026148
 protein coding gene Chr2:92585835-92599446 (+)
A/J MGP_AJ_G0026109
 protein coding gene Chr2:88877216-88889128 (+)
AKR/J MGP_AKRJ_G0026090
 protein coding gene Chr2:91332590-91344228 (+)
BALB/cJ MGP_BALBcJ_G0026118
 protein coding gene Chr2:89057855-89070462 (+)
C3H/HeJ MGP_C3HHeJ_G0025869
 protein coding gene Chr2:91612113-91624414 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026569
 protein coding gene Chr2:95844662-95858497 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023959
 protein coding gene Chr2:85384111-85396378 (+)
CAST/EiJ MGP_CASTEiJ_G0025334
 protein coding gene Chr2:92150136-92163631 (+)
CBA/J MGP_CBAJ_G0025847
 protein coding gene Chr2:99100447-99110908 (+)
DBA/2J MGP_DBA2J_G0025983
 protein coding gene Chr2:88476414-88488161 (+)
FVB/NJ MGP_FVBNJ_G0025946
 protein coding gene Chr2:87585345-87597302 (+)
LP/J MGP_LPJ_G0026087
 protein coding gene Chr2:92794099-92805688 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025972
 protein coding gene Chr2:102134127-102160822 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026623
 protein coding gene Chr2:91403727-91417505 (+)
PWK/PhJ MGP_PWKPhJ_G0025069
 protein coding gene Chr2:88206976-88219573 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024870
 protein coding gene Chr2:90970334-90983610 (+)
WSB/EiJ MGP_WSBEiJ_G0025401
 protein coding gene Chr2:92001685-92014553 (+)



Homology
more
  • Human Ortholog
    ARFGAP2, ARF GTPase activating protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARFGAP2, ARF GTPase activating protein 2
  • Synonyms
    IRZ, NBLA10535, ZFP289, ZNF289
  • Links
    NCBI Gene ID: 84364
    neXtProt AC: NX_Q8N6H7
    UniProt: Q8N6H7

  • Chr Location
    11p11.2; chr11:47164299-47177125 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    777
  • Tissues
    67
  • cDNA Data
    9
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027255 Ensembl Gene Model | MGI Sequence Detail 11958 C57BL/6J ±  kb
transcript ENSMUST00000028691 Ensembl | MGI Sequence Detail 2791 Not Applicable  
polypeptide ENSMUSP00000028691 Ensembl | MGI Sequence Detail 534 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000004207 ADP-ribosylation factor GTPase-activating protein 2
    (term hierarchy)
  • InterPro Domains
    IPR038508 ArfGAP domain superfamily
    IPR037278 ARFGAP/RecO-like zinc finger
    IPR001164 Arf GTPase activating protein
  • GlyGen
    Q99K28 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 12
    cDNA 11
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 43
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:269738 Guerreiro I, et al., Reorganisation of Hoxd regulatory landscapes during the evolution of a snake-like body plan. Elife. 2016 Aug 1;5:e16087
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory