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Tab2 Gene Detail
Summary
  • Symbol
    Tab2
  • Name
    TGF-beta activated kinase 1/MAP3K7 binding protein 2
  • Synonyms
    1110030N06Rik, A530078N03Rik, Map3k7ip2, mKIAA0733, Tak1 binding protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915902
    NCBI Gene: 68652
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:7781417-7831994 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 2.56 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1133 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915902
 protein coding gene Chr10:7781412-7832039 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017002
 protein coding gene Chr10:5134518-5162074 (-)
A/J MGP_AJ_G0016980
 protein coding gene Chr10:4884005-4935193 (-)
AKR/J MGP_AKRJ_G0016944
 protein coding gene Chr10:4979306-5029792 (-)
BALB/cJ MGP_BALBcJ_G0016938
 protein coding gene Chr10:4850718-4901905 (-)
C3H/HeJ MGP_C3HHeJ_G0016763
 protein coding gene Chr10:5117373-5170153 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017400
 protein coding gene Chr10:5268514-5296075 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015105
 protein coding gene Chr10:4466809-4496021 (-)
CAST/EiJ MGP_CASTEiJ_G0016345
 protein coding gene Chr10:5036401-5088284 (-)
CBA/J MGP_CBAJ_G0016735
 protein coding gene Chr10:5429840-5457529 (-)
DBA/2J MGP_DBA2J_G0016843
 protein coding gene Chr10:4812723-4863318 (-)
FVB/NJ MGP_FVBNJ_G0016838
 protein coding gene Chr10:4762167-4789720 (-)
LP/J MGP_LPJ_G0016918
 protein coding gene Chr10:4975526-5031802 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016868
 protein coding gene Chr10:5370983-5428736 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017438
 protein coding gene Chr10:4929266-4956818 (-)
PWK/PhJ MGP_PWKPhJ_G0016130
 protein coding gene Chr10:4789080-4839733 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015912
 protein coding gene Chr10:5010513-5063083 (-)
WSB/EiJ MGP_WSBEiJ_G0016407
 protein coding gene Chr10:4929856-4984127 (-)



Homology
more
  • Human Ortholog
    TAB2, TGF-beta activated kinase 1 (MAP3K7) binding protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAB2, TGF-beta activated kinase 1 (MAP3K7) binding protein 2
  • Synonyms
    CHTD2, MAP3K7IP2, TAB-2
  • Links
    NCBI Gene ID: 23118
    neXtProt AC: NX_Q9NYJ8
    UniProt: Q9NYJ8

  • Chr Location
    6q25.1; chr6:149217926-149411613 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human TAB2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a knock-out allele are viable up to E9.5. Embryos homozygous for a different knock-out allele are normal and viable up to E11.5 but become pale and anemic, exhibit liver hemorrhage and increased apoptosis of hepatoblasts, and die by E12.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    825
  • Tissues
    114
  • cDNA Data
    243
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015755 Ensembl Gene Model | MGI Sequence Detail 50578 C57BL/6J ±  kb
    transcript ENSMUST00000146444 Ensembl | MGI Sequence Detail 4380 Not Applicable  
    polypeptide ENSMUSP00000121266 Ensembl | MGI Sequence Detail 693 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 248
      cDNA 245
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2442803
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 8
      Gene Ontology 9
      Phenotypes 16
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345487 Zhang J, et al., E3 ligase RNF99 negatively regulates TLR-mediated inflammatory immune response via K48-linked ubiquitination of TAB2. Cell Death Differ. 2023 Apr;30(4):966-978
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory