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Stk24 Gene Detail
Summary
  • Symbol
    Stk24
  • Name
    serine/threonine kinase 24
  • Synonyms
    1810013H02Rik, MGC:6330, STE20
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385007
    NCBI Gene: 223255
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:121523755-121617423 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 64.95 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2903 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385007
 protein coding gene Chr14:121521599-121618269 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021661
 protein coding gene Chr14:119070216-119170339 (-)
A/J MGP_AJ_G0021621
 protein coding gene Chr14:114489121-114583165 (-)
AKR/J MGP_AKRJ_G0021597
 protein coding gene Chr14:118189212-118284150 (-)
BALB/cJ MGP_BALBcJ_G0021627
 protein coding gene Chr14:115025856-115122167 (-)
C3H/HeJ MGP_C3HHeJ_G0021405
 protein coding gene Chr14:118082248-118178472 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022067
 protein coding gene Chr14:123671075-123770881 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019605
 protein coding gene Chr14:110385059-110477405 (-)
CAST/EiJ MGP_CASTEiJ_G0020920
 protein coding gene Chr14:115969251-116069913 (-)
CBA/J MGP_CBAJ_G0021373
 protein coding gene Chr14:128369015-128480730 (-)
DBA/2J MGP_DBA2J_G0021496
 protein coding gene Chr14:114361547-114455384 (-)
FVB/NJ MGP_FVBNJ_G0021474
 protein coding gene Chr14:112688517-112786891 (-)
LP/J MGP_LPJ_G0021564
 protein coding gene Chr14:120035869-120129450 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021501
 protein coding gene Chr14:133399762-133496836 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022090
 protein coding gene Chr14:117742513-117838955 (-)
PWK/PhJ MGP_PWKPhJ_G0020664
 protein coding gene Chr14:111399886-111495416 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020502
 protein coding gene Chr14:113953101-114049467 (-)
WSB/EiJ MGP_WSBEiJ_G0020976
 protein coding gene Chr14:118450668-118548166 (-)



Homology
more
  • Human Ortholog
    STK24, serine/threonine kinase 24
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STK24, serine/threonine kinase 24
  • Synonyms
    HEL-S-95, MST3, MST3B, STE20, STK3
  • Links
    NCBI Gene ID: 8428
    neXtProt AC: NX_Q9Y6E0
    UniProt: Q9Y6E0

  • Chr Location
    13q32.2; chr13:98445185-98577940 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
A hypomorphic mutation increases degranulation of, and exocytosis by, neutrophils.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    724
  • Tissues
    14
  • cDNA Data
    14
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063410 Ensembl Gene Model | MGI Sequence Detail 93669 C57BL/6J ±  kb
    transcript ENSMUST00000079817 Ensembl | MGI Sequence Detail 2676 Not Applicable  
    polypeptide ENSMUSP00000078746 Ensembl | MGI Sequence Detail 431 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000002349 serine/threonine-protein kinase 24
      (term hierarchy)
    • EC
      2.7.11.1
    • InterPro Domains
      IPR048288 Programmed cell death protein 10, dimerisation domain
      IPR046409 Programmed cell death protein 10, dimerisation domain superfamily
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR050629 STE20/SPS1-related Proline-Alanine-rich Kinase
    • GlyGen
      Q99KH8 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1353637, MGI:1917013
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 17
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:334566 Yang X, et al., Release of STK24/25 suppression on MEKK3 signaling in endothelial cells confers cerebral cavernous malformation. JCI Insight. 2023 Mar 8;8(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory