Dnajb11 MGI Mouse Gene Detail - MGI:1915088 - DnaJ heat shock protein family (Hsp40) member B11

Symbol

Dnajb11
Name

DnaJ heat shock protein family (Hsp40) member B11
Synonyms

1810031F23Rik, ABBP-2, Dj9, ERdj3

Feature Type

protein coding gene
IDs

MGI:1915088
NCBI Gene: 67838
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr16:22676595-22698384 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 13.71 cM
Mapping Data

2 experiments

SNPs within 2kb

771 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915088	protein coding gene	Chr16:22676595-22698384 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022673	protein coding gene	Chr16:20384057-20408241 (+)
A/J	MGP_AJ_G0022634	protein coding gene	Chr16:19397573-19419365 (+)
AKR/J	MGP_AKRJ_G0022609	protein coding gene	Chr16:20214354-20236143 (+)
BALB/cJ	MGP_BALBcJ_G0022639	protein coding gene	Chr16:19598716-19620511 (+)
C3H/HeJ	MGP_C3HHeJ_G0022403	protein coding gene	Chr16:20319811-20341613 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023089	protein coding gene	Chr16:20825102-20846933 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020607	protein coding gene	Chr16:20090731-20112649 (+)
CAST/EiJ	MGP_CASTEiJ_G0021933	protein coding gene	Chr16:20316657-20338386 (+)
CBA/J	MGP_CBAJ_G0022375	protein coding gene	Chr16:21699279-21721076 (+)
DBA/2J	MGP_DBA2J_G0022507	protein coding gene	Chr16:19378092-19399883 (+)
FVB/NJ	MGP_FVBNJ_G0022483	protein coding gene	Chr16:19348039-19369964 (+)
LP/J	MGP_LPJ_G0022575	protein coding gene	Chr16:20137959-20159748 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022502	protein coding gene	Chr16:21240093-21261881 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023100	protein coding gene	Chr16:20158247-20180057 (+)
PWK/PhJ	MGP_PWKPhJ_G0021673	protein coding gene	Chr16:19620503-19642271 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021503	protein coding gene	Chr16:19947297-19969145 (+)
WSB/EiJ	MGP_WSBEiJ_G0021976	protein coding gene	Chr16:20123812-20145560 (+)

Human Ortholog

DNAJB11, DnaJ heat shock protein family (Hsp40) member B11

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNAJB11, DnaJ heat shock protein family (Hsp40) member B11
Synonyms

ABBP-2, ABBP2, Dj-9, DJ9, EDJ, ERdj3, ERj3, ERj3p, PKD6, PRO1080, UNQ537
Links

HGNC:14889

NCBI Gene ID: 51726

neXtProt AC: NX_Q9UBS4

UniProt: Q9UBS4
Chr Location

3q27.3; chr3:186567403-186585800 (+) GRCh38

MGI Vertebrate Homology

Dnajb11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DNAJB11
Gene Tree

Dnajb11

Diseases

1 with human DNAJB11 associations

				Human Disease	Mouse Models
				polycystic kidney disease 6 IDs polycystic kidney disease 6 DOID:0060951 OMIM:618061

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Gene trapped

3
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

30
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

13
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dnajb11

ZFIN dnajb11

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All Sequences

60
RefSeq

6
UniProt

2
CCDS

CCDS28070.1

Ensembl

ENSMUSG00000004460 (Evidence)
NCBI Gene

67838

			Length	Strain/Species	Flank
genomic	67838	NCBI Gene Model \| MGI Sequence Detail	21790	C57BL/6J	± kb
transcript	NM_026400	RefSeq \| MGI Sequence Detail	2534	C57BL/6
polypeptide	Q99KV1	UniProt \| EBI \| MGI Sequence Detail	358	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000029416 DnaJ homolog subfamily B member 11

(term hierarchy)
InterPro Domains

IPR002939 Chaperone DnaJ, C-terminal

IPR036869 Chaperone J-domain superfamily

IPR001623 DnaJ domain

IPR018253 DnaJ domain, conserved site

IPR051736 DnaJ homolog subfamily B member 11-like

IPR008971 HSP40/DnaJ peptide-binding
GlyGen

Q99KV1 1 site

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All nucleic 14

cDNA 13

Primer pair 1

Microarray probesets 3

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MGI:2146528

Summaries

All 47

Developmental Gene Expression 2

Gene Ontology 11

Phenotypes 10
Earliest

J:63971 Yu M, et al., HEDJ, an Hsp40 co-chaperone localized to the endoplasmic reticulum of human cells. J Biol Chem. 2000 Aug 11;275(32):24984-92
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dnajb11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr137549	Chr16:22676597-22676664 (+)	36 bp
Tssr137550	Chr16:22676666-22676677 (+)	77 bp
Tssr137551	Chr16:22690448-22690486 (+)	13,872 bp
Tssr137552	Chr16:22697709-22697742 (+)	21,131 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24