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Triobp Gene Detail
Summary
  • Symbol
    Triobp
  • Name
    TRIO and F-actin binding protein
  • Synonyms
    EST478828, Mus EST 478828, Tara
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349410
    NCBI Gene: 110253
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:78831924-78890069 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.70 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1601 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349410
 protein coding gene Chr15:78831924-78890069 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022059
 protein coding gene Chr15:79189346-79249117 (+)
A/J MGP_AJ_G0022020
 protein coding gene Chr15:76460429-76518680 (+)
AKR/J MGP_AKRJ_G0021995
 protein coding gene Chr15:78576661-78637378 (+)
BALB/cJ MGP_BALBcJ_G0022026
 protein coding gene Chr15:76428700-76491442 (+)
C3H/HeJ MGP_C3HHeJ_G0021797
 protein coding gene Chr15:78580038-78641802 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022469
 protein coding gene Chr15:82305653-82365168 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019999
 protein coding gene Chr15:72946569-73005851 (+)
CAST/EiJ MGP_CASTEiJ_G0021318
 protein coding gene Chr15:79269934-79330312 (+)
CBA/J MGP_CBAJ_G0021762
 protein coding gene Chr15:84849192-84914797 (+)
DBA/2J MGP_DBA2J_G0021891
 protein coding gene Chr15:75940802-75999488 (+)
FVB/NJ MGP_FVBNJ_G0021869
 protein coding gene Chr15:74957979-75017840 (+)
LP/J MGP_LPJ_G0021959
 protein coding gene Chr15:79383336-79445056 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021889
 protein coding gene Chr15:90014855-90074016 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022483
 protein coding gene Chr15:78600965-78662247 (+)
PWK/PhJ MGP_PWKPhJ_G0021060
 protein coding gene Chr15:75940503-76002458 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020897
 protein coding gene Chr15:78383753-78446265 (+)
WSB/EiJ MGP_WSBEiJ_G0021370
 protein coding gene Chr15:78973303-79032921 (+)



Homology
more
  • Human Ortholog
    TRIOBP, TRIO and F-actin binding protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIOBP, TRIO and F-actin binding protein
  • Synonyms
    DFNB28, dJ37E16.4, HRIHFB2122, TAP68, TARA
  • Links
    NCBI Gene ID: 11078
    neXtProt AC: NX_Q9H2D6
    UniProt: Q9H2D6

  • Chr Location
    22q13.1; chr22:37697048-37776556 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Triobp mouse models; 1 with human TRIOBP associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 4 alleles in 3 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for gene trapped alleles exhibit embryonic lethality. Mice homozygous for a targeted allele eliminating isoforms 4 and 5 exhibit profound deafness associated with stereocilia fragility and degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    99
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110253 NCBI Gene Model | MGI Sequence Detail 58146 C57BL/6J ±  kb
    transcript NM_001039156 RefSeq | MGI Sequence Detail 7352 ZRU/MplStud  
    polypeptide Q99KW3 UniProt | EBI | MGI Sequence Detail 2014 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 99
      cDNA 99

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1349446, MGI:2146002
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 4
      Diseases 2
      Gene Ontology 10
      Phenotypes 34
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory