Mbip MGI Mouse Gene Detail - MGI:1918320 - MAP3K12 binding inhibitory protein 1

Symbol

Mbip
Name

MAP3K12 binding inhibitory protein 1
Synonyms

4933408E06Rik, MGC:7681

Feature Type

protein coding gene
IDs

MGI:1918320
NCBI Gene: 217588
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr12:56375091-56392681 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 24.30 cM
Mapping Data

1 experiment

SNPs within 2kb

528 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918320	protein coding gene	Chr12:56375088-56392681 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019754	protein coding gene	Chr12:55433521-55451618 (-)
A/J	MGP_AJ_G0019713	protein coding gene	Chr12:53428222-53445810 (-)
AKR/J	MGP_AKRJ_G0019688	protein coding gene	Chr12:55105801-55123406 (-)
BALB/cJ	MGP_BALBcJ_G0019693	protein coding gene	Chr12:53769970-53787517 (-)
C3H/HeJ	MGP_C3HHeJ_G0019498	protein coding gene	Chr12:55173956-55191544 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020145	protein coding gene	Chr12:57079989-57097511 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017765	protein coding gene	Chr12:51893843-51911508 (-)
CAST/EiJ	MGP_CASTEiJ_G0019050	protein coding gene	Chr12:50058488-50081290 (-)
CBA/J	MGP_CBAJ_G0019467	protein coding gene	Chr12:59093335-59110973 (-)
DBA/2J	MGP_DBA2J_G0019583	protein coding gene	Chr12:53328104-53345979 (-)
FVB/NJ	MGP_FVBNJ_G0019571	protein coding gene	Chr12:52624838-52642403 (-)
LP/J	MGP_LPJ_G0019655	protein coding gene	Chr12:55401534-55420186 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019609	protein coding gene	Chr12:60650406-60671147 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020179	protein coding gene	Chr12:54551462-54569030 (-)
PWK/PhJ	MGP_PWKPhJ_G0018817	protein coding gene	Chr12:47690862-47708843 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018610	protein coding gene	Chr12:48970150-48998533 (-)
WSB/EiJ	MGP_WSBEiJ_G0019101	protein coding gene	Chr12:55066681-55085706 (-)

Human Ortholog

MBIP, MAP3K12 binding inhibitory protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MBIP, MAP3K12 binding inhibitory protein 1
Links

HGNC:20427

NCBI Gene ID: 51562

neXtProt AC: NX_Q9NS73

UniProt: Q9NS73
Chr Location

14q13.3; chr14:36298564-36320637 (-) GRCh38

MGI Vertebrate Homology

Mbip stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MBIP
Gene Tree

Mbip

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
1 images
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

2
Targeted

3
Genomic Mutations

1 involving Mbip
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available

Mice homozygous for a knock-out allele show complete embryonic lethality by E7.5. In vitro outgrowth assays show that blastocysts hatch from the zona pellucida but form irregular outgrowths.

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All GO Annotations

38
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

756
Tissues

12
cDNA Data

24
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mbip

ZFIN mbip

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All Sequences

47
RefSeq

14
UniProt

2
CCDS

CCDS25920.1

Ensembl

ENSMUSG00000021028 (Evidence)
NCBI Gene

217588

			Length	Strain/Species	Flank
genomic	217588	NCBI Gene Model \| MGI Sequence Detail	17591	C57BL/6J	± kb
transcript	NM_145442	RefSeq \| MGI Sequence Detail	1509	C57BL/6
polypeptide	Q99LQ1	UniProt \| EBI \| MGI Sequence Detail	341	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010219 MAP3K12-binding inhibitory protein 1

(term hierarchy)

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All nucleic 28

cDNA 25

Primer pair 2

Other 1

Microarray probesets 3

Summaries

All 43

Developmental Gene Expression 5

Gene Ontology 8

Phenotypes 13
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mbip:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116366	Chr12:56392647-56392673 (-)	21 bp
Tssr116365	Chr12:56392577-56392627 (-)	79 bp
Tssr116364	Chr12:56392557-56392573 (-)	116 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24