Pigx MGI Mouse Gene Detail - MGI:1919334 - phosphatidylinositol glycan anchor biosynthesis, class X

Symbol

Pigx
Name

phosphatidylinositol glycan anchor biosynthesis, class X
Synonyms

2010319C14Rik

Feature Type

protein coding gene
IDs

MGI:1919334
NCBI Gene: 72084
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr16:31903234-31918545 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 22.40 cM, cytoband B2
Mapping Data

2 experiments

SNPs within 2kb

569 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919334	protein coding gene	Chr16:31903234-31918558 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022728	protein coding gene	Chr16:30109886-30133122 (-)
A/J	MGP_AJ_G0022693	protein coding gene	Chr16:28714585-28729373 (-)
AKR/J	MGP_AKRJ_G0022666	protein coding gene	Chr16:29757554-29774327 (-)
BALB/cJ	MGP_BALBcJ_G0022695	protein coding gene	Chr16:28865899-28882086 (-)
C3H/HeJ	MGP_C3HHeJ_G0022460	protein coding gene	Chr16:29880818-29896898 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023144	protein coding gene	Chr16:30760097-30779085 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020662	protein coding gene	Chr16:29086909-29103427 (-)
CAST/EiJ	MGP_CASTEiJ_G0021988	protein coding gene	Chr16:30010984-30027312 (-)
CBA/J	MGP_CBAJ_G0022430	protein coding gene	Chr16:32018155-32034753 (-)
DBA/2J	MGP_DBA2J_G0022563	protein coding gene	Chr16:28566778-28583167 (-)
FVB/NJ	MGP_FVBNJ_G0022538	protein coding gene	Chr16:28550722-28565444 (-)
LP/J	MGP_LPJ_G0022630	protein coding gene	Chr16:29895467-29913178 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022557	protein coding gene	Chr16:31471816-31486789 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023156	protein coding gene	Chr16:29734769-29752394 (-)
PWK/PhJ	MGP_PWKPhJ_G0021727	protein coding gene	Chr16:28882669-28899633 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021558	protein coding gene	Chr16:29525551-29550554 (-)
WSB/EiJ	MGP_WSBEiJ_G0022032	protein coding gene	Chr16:29675373-29690935 (-)

Human Ortholog

PIGX, phosphatidylinositol glycan anchor biosynthesis class X

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PIGX, phosphatidylinositol glycan anchor biosynthesis class X
Synonyms

PIG-X
Links

HGNC:26046

NCBI Gene ID: 54965

neXtProt AC: NX_Q8TBF5

UniProt: Q8TBF5
Chr Location

3q29; chr3:196639775-196736007 (+) GRCh38

MGI Vertebrate Homology

Pigx stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PIGX
Gene Tree

Pigx

less

Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

69
Endonuclease-mediated

4
Gene trapped

63
Targeted

2
Genomic Mutations

1 involving Pigx
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

18 strains or lines available

less

All GO Annotations

2
GO References

2

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

808
Tissues

99
cDNA Data

63
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pigx

less

All Sequences

62
RefSeq

4
UniProt

9
CCDS

CCDS28113.2, CCDS49824.1

Ensembl

ENSMUSG00000023791 (Evidence)
NCBI Gene

72084

			Length	Strain/Species	Flank
genomic	72084	NCBI Gene Model \| MGI Sequence Detail	15312	C57BL/6J	± kb
transcript	NM_024464	RefSeq \| MGI Sequence Detail	1019	C57BL/6
polypeptide	Q99LV7	UniProt \| EBI \| MGI Sequence Detail	254	Not Applicable

less

UniProt

9 Sequences
Protein Ontology

PR:000012711 phosphatidylinositol-glycan biosynthesis class X protein

(term hierarchy)
InterPro Domains

IPR013233 Glycosylphosphatidylinositol-mannosyltransferase I, PIG-X/PBN1

IPR040039 Phosphatidylinositol-glycan biosynthesis class X protein
GlyGen

Q99LV7 1 site

less

All nucleic 64

cDNA 63

Primer pair 1

Microarray probesets 4

Summaries

All 36

Developmental Gene Expression 4

Gene Ontology 2

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pigx:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr140778	Chr16:31918515-31918570 (-)	2 bp
Tssr140777	Chr16:31918487-31918514 (-)	44 bp
Tssr140776	Chr16:31918438-31918453 (-)	99 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24