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Ms4a6d Gene Detail
Summary
  • Symbol
    Ms4a6d
  • Name
    membrane-spanning 4-domains, subfamily A, member 6D
  • Synonyms
    Ms4a11
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916024
    NCBI Gene: 68774
  • Member of
    Ms4ac cluster
  • Alliance
    gene page
  • Transcription Start Sites
    31 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:11563970-11582150 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 8.45 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    463 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916024
 protein coding gene Chr19:11563968-11582213 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0024852
 protein coding gene Chr19:8464847-8478020 (-)
AKR/J MGP_AKRJ_G0024827
 protein coding gene Chr19:8790402-8800134 (-)
BALB/cJ MGP_BALBcJ_G0024852
 protein coding gene Chr19:8468734-8482529 (-)
C3H/HeJ MGP_C3HHeJ_G0024618
 protein coding gene Chr19:8689270-8702810 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025300
 protein coding gene Chr19:9428707-9439951 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022724
 protein coding gene Chr19:8831351-8842564 (-)
CAST/EiJ MGP_CASTEiJ_G0024091
 protein coding gene Chr19:8281059-8292477 (-)
CBA/J MGP_CBAJ_G0024592
 protein coding gene Chr19:9486020-9497269 (-)
DBA/2J MGP_DBA2J_G0024719
 protein coding gene Chr19:8434223-8449150 (-)
FVB/NJ MGP_FVBNJ_G0024686
 protein coding gene Chr19:8471958-8484354 (-)
LP/J MGP_LPJ_G0024806
 protein coding gene Chr19:8982535-8994576 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024713
 protein coding gene Chr19:9382676-9395143 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025348
 protein coding gene Chr19:8772372-8788708 (-)
PWK/PhJ MGP_PWKPhJ_G0023835
 protein coding gene Chr19:7894404-7906065 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023641
 protein coding gene Chr19:7932987-7944391 (-)
WSB/EiJ MGP_WSBEiJ_G0024153
 protein coding gene Chr19:8626589-8638541 (-)



Homology
more
  • Human Ortholog
    MS4A6A, membrane spanning 4-domains A6A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MS4A6A, membrane spanning 4-domains A6A
  • Synonyms
    4SPAN3, 4SPAN3.2, CD20L3, CDA01, MS4A6, MST090, MSTP090
  • Links
    NCBI Gene ID: 64231
    neXtProt AC: NX_Q9H2W1
    UniProt: Q9H2W1

  • Chr Location
    11q12.2; chr11:60171607-60184666 (-)  GRCh38
  • Human Ortholog
    MS4A6E, membrane spanning 4-domains A6E
  • Links
    NCBI Gene ID: 245802
    neXtProt AC: NX_Q96DS6
    UniProt: Q96DS6

  • Chr Location
    11q12.2; chr11:60327255-60396596 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 3 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit decreased susceptibility to LPS-induced endotoxin lethality with lower proinflammatory cytokine levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    24
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 68774 NCBI Gene Model | MGI Sequence Detail 18181 C57BL/6J ±  kb
transcript NM_026835 RefSeq | MGI Sequence Detail 1353 C57BL/6  
polypeptide Q99N07 UniProt | EBI | MGI Sequence Detail 247 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 24

    Microarray probesets 5
Other
Accession IDs
less
MGI:1927659, MGI:2147536
References
more
  • Summaries
    All 40
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:346402 Guo J, et al., MS4A6D Promotes carrageenan-induced footpad swelling in mice through enhancing macrophages-derived inflammation. Mol Immunol. 2024 Mar 16;169:28-36
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory