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Atoh8 Gene Detail
Summary
  • Symbol
    Atoh8
  • Name
    atonal bHLH transcription factor 8
  • Synonyms
    4933425C05Rik, bHLHa21, Math6, okadin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918343
    NCBI Gene: 71093
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:72183161-72212561 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 32.27 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    757 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918343
 protein coding gene Chr6:72183158-72212765 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030868
 protein coding gene Chr6:72737086-72767627 (-)
A/J MGP_AJ_G0030838
 protein coding gene Chr6:69926633-69956024 (-)
AKR/J MGP_AKRJ_G0030767
 protein coding gene Chr6:71970703-72000872 (-)
BALB/cJ MGP_BALBcJ_G0030849
 protein coding gene Chr6:69955220-69984435 (-)
C3H/HeJ MGP_C3HHeJ_G0030863
 protein coding gene Chr6:112226861-112259687 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031307
 protein coding gene Chr6:74655743-74690611 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028496
 protein coding gene Chr6:69072594-69102910 (-)
CAST/EiJ MGP_CASTEiJ_G0029957
 protein coding gene Chr6:71832121-71870350 (-)
CBA/J MGP_CBAJ_G0030536
 protein coding gene Chr6:77678760-77718923 (-)
DBA/2J MGP_DBA2J_G0030688
 protein coding gene Chr6:69322225-69352661 (-)
FVB/NJ MGP_FVBNJ_G0030641
 protein coding gene Chr6:68691489-68722294 (-)
LP/J MGP_LPJ_G0030767
 protein coding gene Chr6:72649132-72681404 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030676
 protein coding gene Chr6:81090025-81123073 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031333
 protein coding gene Chr6:71787597-71817658 (-)
PWK/PhJ MGP_PWKPhJ_G0029673
 protein coding gene Chr6:68220674-68252226 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029501
 protein coding gene Chr6:70528031-70558469 (-)
WSB/EiJ MGP_WSBEiJ_G0030039
 protein coding gene Chr6:72159172-72191340 (-)



Homology
more
  • Human Ortholog
    ATOH8, atonal bHLH transcription factor 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATOH8, atonal bHLH transcription factor 8
  • Synonyms
    bHLHa21, HATH6
  • Links
    NCBI Gene ID: 84913
    neXtProt AC: NX_Q96SQ7
    UniProt: Q96SQ7

  • Chr Location
    2p11.2; chr2:85751344-85791383 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 4 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-in allele appear to be developmentally arrested at or slightly after gastrulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    41
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    985
  • Tissues
    217
  • cDNA Data
    25
  • Literature Summary
    19
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037621 Ensembl Gene Model | MGI Sequence Detail 29401 C57BL/6J ±  kb
transcript ENSMUST00000042646 Ensembl | MGI Sequence Detail 2355 Not Applicable  
polypeptide ENSMUSP00000036981 Ensembl | MGI Sequence Detail 322 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000004432 transcription factor ATOH8
    (term hierarchy)
  • InterPro Domains
    IPR050359 Basic helix-loop-helix transcription factors
    IPR036638 Helix-loop-helix DNA-binding domain superfamily
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR032660 Transcription factor ATOH8, basic helix-loop-helix domain
Molecular
Reagents
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  • All nucleic 31
    cDNA 25
    Primer pair 4
    Other 2

    Microarray probesets 3
References
more
  • Summaries
    All 56
    Developmental Gene Expression 19
    Gene Ontology 11
    Phenotypes 13
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:328307 Divvela SSK, et al., Atonal homolog 8/Math6 regulates differentiation and maintenance of skeletal muscle. Front Cell Dev Biol. 2022;10:950414
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory