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Pard3 Gene Detail
Summary
  • Symbol
    Pard3
  • Name
    par-3 family cell polarity regulator
  • Synonyms
    ASIP, D8Ertd580e, Par3, PAR-3, Pard3a
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135608
    NCBI Gene: 93742
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:127790643-128338767 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 74.66 cM, cytoband E2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    14337 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135608
 protein coding gene Chr8:127790131-128338767 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034299
 protein coding gene Chr8:130939011-131522596 (+)
A/J MGP_AJ_G0034278
 protein coding gene Chr8:125513940-126061996 (+)
AKR/J MGP_AKRJ_G0034205
 protein coding gene Chr8:129112479-129688962 (+)
BALB/cJ MGP_BALBcJ_G0034271
 protein coding gene Chr8:125676261-126231263 (+)
C3H/HeJ MGP_C3HHeJ_G0033982
 protein coding gene Chr8:129768041-130335434 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034791
 protein coding gene Chr8:135243805-135813861 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031733
 protein coding gene Chr8:118178479-118720909 (+)
CAST/EiJ MGP_CASTEiJ_G0033309
 protein coding gene Chr8:129945569-130522589 (+)
CBA/J MGP_CBAJ_G0033956
 protein coding gene Chr8:140281065-140877715 (+)
DBA/2J MGP_DBA2J_G0034111
 protein coding gene Chr8:124612853-125153703 (+)
FVB/NJ MGP_FVBNJ_G0034056
 protein coding gene Chr8:123846497-124394841 (+)
LP/J MGP_LPJ_G0034200
 protein coding gene Chr8:131101768-131682858 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034102
 protein coding gene Chr8:142185072-142783633 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034810
 protein coding gene Chr8:129348042-129915908 (+)
PWK/PhJ MGP_PWKPhJ_G0033012
 protein coding gene Chr8:124422006-124978422 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032850
 protein coding gene Chr8:127990020-128581281 (+)
WSB/EiJ MGP_WSBEiJ_G0033427
 protein coding gene Chr8:130093725-130675508 (+)



Homology
more
  • Human Ortholog
    PARD3, par-3 family cell polarity regulator
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PARD3, par-3 family cell polarity regulator
  • Synonyms
    ASIP, Baz, PAR3, PAR3alpha, PARD-3, PARD3A, PPP1R118, SE2-5L16, SE2-5LT1, SE2-5T2
  • Links
    NCBI Gene ID: 56288
    neXtProt AC: NX_Q8TEW0
    UniProt: Q8TEW0

  • Chr Location
    10p11.22-p11.21; chr10:34109560-34815325 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 3 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality at E12.5 associated with growth retardation, abnormal heart development, and abnormal epicardial cell development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    76
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    848
  • Tissues
    89
  • cDNA Data
    131
  • Literature Summary
    140
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025812 Ensembl Gene Model | MGI Sequence Detail 548125 C57BL/6J ±  kb
    transcript ENSMUST00000160272 Ensembl | MGI Sequence Detail 5815 Not Applicable  
    polypeptide ENSMUSP00000125453 Ensembl | MGI Sequence Detail 1334 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 133
      cDNA 132
      Primer pair 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1261826, MGI:2142456, MGI:2142486
    References
    more
    • Summaries
      All 232
      Developmental Gene Expression 140
      Gene Ontology 22
      Phenotypes 37
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:352151 Voglewede MM, et al., Loss of the polarity protein Par3 promotes dendritic spine neoteny and enhances learning and memory. iScience. 2024 Jul 19;27(7):110308
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory