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Trem2 Gene Detail
Summary
  • Symbol
    Trem2
  • Name
    triggering receptor expressed on myeloid cells 2
  • Synonyms
    Trem2a, Trem2b, Trem2c
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913150
    NCBI Gene: 83433
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:48653429-48659304 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 23.99 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    381 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913150
 protein coding gene Chr17:48653429-48661175 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023869
 protein coding gene Chr17:49625840-49633529 (+)
A/J MGP_AJ_G0023829
 protein coding gene Chr17:48324507-48332252 (+)
AKR/J MGP_AKRJ_G0023797
 protein coding gene Chr17:48805311-48813006 (+)
BALB/cJ MGP_BALBcJ_G0023831
 protein coding gene Chr17:48248712-48256458 (+)
C3H/HeJ MGP_C3HHeJ_G0023594
 protein coding gene Chr17:49511356-49519102 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024274
 protein coding gene Chr17:51737233-51744979 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021723
 protein coding gene Chr17:45081285-45089090 (+)
CAST/EiJ MGP_CASTEiJ_G0023076
 protein coding gene Chr17:49696346-49703692 (+)
CBA/J MGP_CBAJ_G0023570
 protein coding gene Chr17:53597043-53604789 (+)
DBA/2J MGP_DBA2J_G0023699
 protein coding gene Chr17:47090176-47098306 (+)
FVB/NJ MGP_FVBNJ_G0023665
 protein coding gene Chr17:46755822-46763568 (+)
LP/J MGP_LPJ_G0023779
 protein coding gene Chr17:50331984-50341362 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023693
 protein coding gene Chr17:53076028-53083774 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024320
 protein coding gene Chr17:49135814-49143545 (+)
PWK/PhJ MGP_PWKPhJ_G0022821
 protein coding gene Chr17:46528125-46535886 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022635
 protein coding gene Chr17:46044092-46051706 (+)
WSB/EiJ MGP_WSBEiJ_G0023140
 protein coding gene Chr17:49734886-49743394 (+)



Homology
more
  • Human Ortholog
    TREM2, triggering receptor expressed on myeloid cells 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TREM2, triggering receptor expressed on myeloid cells 2
  • Synonyms
    PLOSL2, TREM-2, Trem2a, Trem2b, Trem2c
  • Links
    NCBI Gene ID: 54209
    neXtProt AC: NX_Q9NZC2
    UniProt: Q9NZC2

  • Chr Location
    6p21.1; chr6:41158506-41163186 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Trem2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    172 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display enhanced cytokine production by macrophages in response to toll-like receptor agonists. Mice homozygous for a different knock-out allele show reduced microglial cell survival, proliferation and activation and cell cycle arrest at the G1/S checkpoint.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    213
  • GO References
    42
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    793
  • Tissues
    36
  • cDNA Data
    25
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 83433 NCBI Gene Model | MGI Sequence Detail 5876 C57BL/6J ±  kb
    transcript NM_001272078 RefSeq | MGI Sequence Detail 1069 C57BL/6  
    polypeptide Q99NH8 UniProt | EBI | MGI Sequence Detail 227 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 25
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1932924, MGI:1932925
    References
    more
    • Summaries
      All 271
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 42
      Phenotypes 172
    • Earliest
      J:64954 Bouchon A, et al., Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol. 2000 May 15;164(10):4991-5
    • Latest
      J:353923 Ganguly S, et al., Lipid-associated macrophages' promotion of fibrosis resolution during MASH regression requires TREM2. Proc Natl Acad Sci U S A. 2024 Aug 27;121(35):e2405746121
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory