Tsnaxip1 MGI Mouse Gene Detail - MGI:1919486 - translin-associated factor X (Tsnax) interacting protein 1

Symbol

Tsnaxip1
Name

translin-associated factor X (Tsnax) interacting protein 1
Synonyms

1700016K08Rik, TXI1

Feature Type

protein coding gene
IDs

MGI:1919486
NCBI Gene: 72236
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr8:106554363-106571312 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 53.04 cM, cytoband D2
Mapping Data

2 experiments

SNPs within 2kb

341 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919486	protein coding gene	Chr8:106554343-106571312 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034060	protein coding gene	Chr8:108142215-108161510 (+)
A/J	MGP_AJ_G0034041	protein coding gene	Chr8:103818765-103836455 (+)
AKR/J	MGP_AKRJ_G0033967	protein coding gene	Chr8:106814928-106838290 (+)
BALB/cJ	MGP_BALBcJ_G0034034	protein coding gene	Chr8:104007584-104024424 (+)
C3H/HeJ	MGP_C3HHeJ_G0033746	protein coding gene	Chr8:107562932-107581430 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034554	protein coding gene	Chr8:112112986-112133169 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031496	protein coding gene	Chr8:96960515-96978000 (+)
CAST/EiJ	MGP_CASTEiJ_G0033072	protein coding gene	Chr8:107076085-107096215 (+)
CBA/J	MGP_CBAJ_G0033719	protein coding gene	Chr8:115713236-115736434 (+)
DBA/2J	MGP_DBA2J_G0033874	protein coding gene	Chr8:103165712-103183456 (+)
FVB/NJ	MGP_FVBNJ_G0033820	protein coding gene	Chr8:102095809-102114030 (+)
LP/J	MGP_LPJ_G0033965	protein coding gene	Chr8:108351921-108373865 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033863	protein coding gene	Chr8:118912382-118934417 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034572	protein coding gene	Chr8:106782966-106804537 (+)
PWK/PhJ	MGP_PWKPhJ_G0032773	protein coding gene	Chr8:102567722-102585982 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032614	protein coding gene	Chr8:105476911-105492010 (+)
WSB/EiJ	MGP_WSBEiJ_G0033188	protein coding gene	Chr8:107471046-107490788 (+)

Human Ortholog

TSNAXIP1, translin associated factor X interacting protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TSNAXIP1, translin associated factor X interacting protein 1
Synonyms

TXI1
Links

HGNC:18586

NCBI Gene ID: 55815

neXtProt AC: NX_Q2TAA8

UniProt: Q2TAA8
Chr Location

16q22.1; chr16:67806765-67832148 (+) GRCh38

MGI Vertebrate Homology

Tsnaxip1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TSNAXIP1
Gene Tree

Tsnaxip1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
3 phenotypes from multigenic genotypes
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Endonuclease-mediated

1
Gene trapped

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Males homozygous for a null allele show reduced male fertility and impaired sperm motility with asymmetric flagellar waveforms.

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All GO Annotations

6
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

729
Tissues

10
cDNA Data

10
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

38
RefSeq

6
UniProt

3
CCDS

CCDS22614.1

Ensembl

ENSMUSG00000031893 (Evidence)
NCBI Gene

72236

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031893	Ensembl Gene Model \| MGI Sequence Detail	16950	C57BL/6J	± kb
transcript	ENSMUST00000034365	Ensembl \| MGI Sequence Detail	2210	Not Applicable
polypeptide	ENSMUSP00000034365	Ensembl \| MGI Sequence Detail	704	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000016733 translin-associated factor X-interacting protein 1

(term hierarchy)
InterPro Domains

IPR032755 Translin-associated factor X-interacting protein 1, N-terminal

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All nucleic 11

cDNA 10

Primer pair 1

Microarray probesets 3

Summaries

All 27

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 3
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:340908 Kaneda Y, et al., Testis-specific proteins, TSNAXIP1 and 1700010I14RIK, are important for sperm motility and male fertility in mice. Andrology. 2023 Jul;11(5):799-807

TSS for Tsnaxip1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79188	Chr8:106554353-106554383 (+)	5 bp
Tssr79189	Chr8:106554385-106554401 (+)	30 bp
Tssr79190	Chr8:106554402-106554405 (+)	41 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24