Fbxo32 MGI Mouse Gene Detail - MGI:1914981

Symbol

Fbxo32
Name

F-box protein 32
Synonyms

4833442G10Rik, atrogin-1, ATROGIN1, MAFbx

Feature Type

protein coding gene
IDs

MGI:1914981
NCBI Gene: 67731
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:58039275-58078288 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 24.43 cM, cytoband D2
Mapping Data

4 experiments

SNPs within 2kb

1096 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914981	protein coding gene	Chr15:58039275-58078328 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021870	protein coding gene	Chr15:57338071-57377056 (-)
A/J	MGP_AJ_G0021830	protein coding gene	Chr15:55088779-55127711 (-)
AKR/J	MGP_AKRJ_G0021811	protein coding gene	Chr15:56618572-56657433 (-)
BALB/cJ	MGP_BALBcJ_G0021837	protein coding gene	Chr15:55314212-55353542 (-)
C3H/HeJ	MGP_C3HHeJ_G0021611	protein coding gene	Chr15:56739299-56778271 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022276	protein coding gene	Chr15:59576602-59615574 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019813	protein coding gene	Chr15:52194668-52233969 (-)
CAST/EiJ	MGP_CASTEiJ_G0021128	protein coding gene	Chr15:57386409-57428547 (-)
CBA/J	MGP_CBAJ_G0021580	protein coding gene	Chr15:61632567-61676563 (-)
DBA/2J	MGP_DBA2J_G0021704	protein coding gene	Chr15:55013650-55052960 (-)
FVB/NJ	MGP_FVBNJ_G0021682	protein coding gene	Chr15:54067676-54107014 (-)
LP/J	MGP_LPJ_G0021774	protein coding gene	Chr15:57187536-57226553 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021706	protein coding gene	Chr15:66720359-66760898 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022299	protein coding gene	Chr15:57027530-57066515 (-)
PWK/PhJ	MGP_PWKPhJ_G0020873	protein coding gene	Chr15:55018100-55057716 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020710	protein coding gene	Chr15:56803316-56847139 (-)
WSB/EiJ	MGP_WSBEiJ_G0021183	protein coding gene	Chr15:57017105-57056838 (-)

Human Ortholog

FBXO32, F-box protein 32

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FBXO32, F-box protein 32
Synonyms

Fbx32, MAFbx
Links

HGNC:16731

NCBI Gene ID: 114907

neXtProt AC: NX_Q969P5

UniProt: Q969P5
Chr Location

8q24.13; chr8:123497889-123541206 (-) GRCh38

MGI Vertebrate Homology

Fbxo32 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FBXO32
Gene Tree

Fbxo32

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

3
Endonuclease-mediated

2
Radiation induced

2
Targeted

3
Genomic Mutations

5 involving Fbxo32
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

A targeted homozygous mutation in this gene results in resistance to skeletal muscle atrophy in response to nerve injury.

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All GO Annotations

23
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

790
Tissues

28
cDNA Data

55
Literature Summary

19

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fbxo32

ZFIN fbxo32

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All Sequences

39
RefSeq

2
UniProt

1
CCDS

CCDS27491.1

Ensembl

ENSMUSG00000022358 (Evidence)
NCBI Gene

67731

			Length	Strain/Species	Flank
genomic	67731	NCBI Gene Model \| MGI Sequence Detail	39014	C57BL/6J	± kb
transcript	NM_026346	RefSeq \| MGI Sequence Detail	6936	C57BL/6
polypeptide	Q9CPU7	UniProt \| EBI \| MGI Sequence Detail	355	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000007402 F-box only protein 32

(term hierarchy)
InterPro Domains

IPR036047 F-box-like domain superfamily

IPR040394 F-box only protein 25/32

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All nucleic 59

cDNA 55

Primer pair 3

Other 1

Microarray probesets 4

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MGI:2146006

Summaries

All 104

Developmental Gene Expression 19

Diseases 1

Gene Ontology 11

Phenotypes 35
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:326089 Ghnaimawi S, et al., The Effects of Maternal Intake of EPA and DHA Enriched Diet During Pregnancy and Lactation on Offspring's Muscle Development and Energy Homeostasis. Front Physiol. 2022;13:881624

TSS for Fbxo32:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr134396	Chr15:58078278-58078322 (-)	-12 bp
Tssr134395	Chr15:58078233-58078244 (-)	49 bp
Tssr134394	Chr15:58054807-58054836 (-)	23,466 bp
Tssr134393	Chr15:58046373-58046377 (-)	31,913 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24