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Med21 Gene Detail
Summary
  • Symbol
    Med21
  • Name
    mediator complex subunit 21
  • Synonyms
    0610007L03Rik, D6Ertd782e, Srb7, Surb7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347064
    NCBI Gene: 108098
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:146544077-146552098 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 77.70 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    140 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347064
 protein coding gene Chr6:146544045-146552230 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031489
 protein coding gene Chr6:151671040-151680386 (+)
A/J MGP_AJ_G0031464
 protein coding gene Chr6:145667395-145675107 (+)
AKR/J MGP_AKRJ_G0031392
 protein coding gene Chr6:149983230-149991373 (+)
BALB/cJ MGP_BALBcJ_G0031472
 protein coding gene Chr6:145405647-145413837 (+)
C3H/HeJ MGP_C3HHeJ_G0031193
 protein coding gene Chr6:150051788-150059940 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031933
 protein coding gene Chr6:155720647-155729268 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029057
 protein coding gene Chr6:144380644-144387598 (+)
CAST/EiJ MGP_CASTEiJ_G0030561
 protein coding gene Chr6:149681269-149689241 (+)
CBA/J MGP_CBAJ_G0031153
 protein coding gene Chr6:161668009-161675962 (+)
DBA/2J MGP_DBA2J_G0031309
 protein coding gene Chr6:144448369-144456461 (+)
FVB/NJ MGP_FVBNJ_G0031261
 protein coding gene Chr6:143177993-143186433 (+)
LP/J MGP_LPJ_G0031394
 protein coding gene Chr6:151763011-151771045 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031301
 protein coding gene Chr6:165399634-165407473 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031966
 protein coding gene Chr6:149812191-149821199 (+)
PWK/PhJ MGP_PWKPhJ_G0030288
 protein coding gene Chr6:142960182-142969460 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030112
 protein coding gene Chr6:147962368-147971079 (+)
WSB/EiJ MGP_WSBEiJ_G0030654
 protein coding gene Chr6:150443191-150454743 (+)



Homology
more
  • Human Ortholog
    MED21, mediator complex subunit 21
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MED21, mediator complex subunit 21
  • Synonyms
    hSrb7, SRB7, SURB7
  • Links
    NCBI Gene ID: 9412
    neXtProt AC: NX_Q13503
    UniProt: Q13503

  • Chr Location
    12p11.23; chr12:27022546-27066343 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a targeted null mutation die at the blastocyst stage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    914
  • Tissues
    109
  • cDNA Data
    62
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 108098 NCBI Gene Model | MGI Sequence Detail 8022 C57BL/6J ±  kb
transcript NM_025315 RefSeq | MGI Sequence Detail 780 ZRU/MplStud  
polypeptide Q9CQ39 UniProt | EBI | MGI Sequence Detail 144 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 64
    cDNA 62
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:1289181, MGI:1913295, MGI:2141415, MGI:2141792
References
more
  • Summaries
    All 43
    Developmental Gene Expression 4
    Gene Ontology 12
    Phenotypes 6
  • Earliest
    J:57760 Tudor M, et al., Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit Srb7 in mice. Genes Dev. 1999 Sep 15;13(18):2365-8
  • Latest
    J:347774 Kolonay DW, et al., Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease. Front Cell Dev Biol. 2024;12:1331563
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory