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Itgb3bp Gene Detail
Summary
  • Symbol
    Itgb3bp
  • Name
    integrin beta 3 binding protein (beta3-endonexin)
  • Synonyms
    4930471O16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914983
    NCBI Gene: 67733
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:99655643-99717403 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 45.71 cM, cytoband C6
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1250 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914983
 protein coding gene Chr4:99653639-99787010 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028483
 protein coding gene Chr4:100028831-100172314 (-)
A/J MGP_AJ_G0028446
 protein coding gene Chr4:96537374-96672415 (-)
AKR/J MGP_AKRJ_G0028393
 protein coding gene Chr4:98873151-99015453 (-)
BALB/cJ MGP_BALBcJ_G0028464
 protein coding gene Chr4:96782398-96926027 (-)
C3H/HeJ MGP_C3HHeJ_G0028177
 protein coding gene Chr4:99697761-99840705 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028903
 protein coding gene Chr4:103819999-103972904 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026195
 protein coding gene Chr4:91911393-92040429 (-)
CAST/EiJ MGP_CASTEiJ_G0027617
 protein coding gene Chr4:97484479-97620298 (-)
CBA/J MGP_CBAJ_G0028146
 protein coding gene Chr4:107021976-107206169 (-)
DBA/2J MGP_DBA2J_G0028296
 protein coding gene Chr4:96257682-96392695 (-)
FVB/NJ MGP_FVBNJ_G0028263
 protein coding gene Chr4:95106808-95238956 (-)
LP/J MGP_LPJ_G0028396
 protein coding gene Chr4:100328379-100482487 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028291
 protein coding gene Chr4:112711245-112843624 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028941
 protein coding gene Chr4:99126103-99265768 (-)
PWK/PhJ MGP_PWKPhJ_G0027342
 protein coding gene Chr4:94412474-94549583 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027164
 protein coding gene Chr4:96572134-96721118 (-)
WSB/EiJ MGP_WSBEiJ_G0027695
 protein coding gene Chr4:99276284-99432121 (-)



Homology
more
  • Human Ortholog
    ITGB3BP, integrin subunit beta 3 binding protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGB3BP, integrin subunit beta 3 binding protein
  • Synonyms
    CENP-R, CENPR, HSU37139, NRIF3, TAP20
  • Links
    NCBI Gene ID: 23421
    neXtProt AC: NX_Q13352
    UniProt: Q13352

  • Chr Location
    1p31.3; chr1:63440770-63593721 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    8
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    30
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 67733 NCBI Gene Model | MGI Sequence Detail 61761 C57BL/6J ±  kb
transcript NM_026348 RefSeq | MGI Sequence Detail 774 C57BL/6  
polypeptide Q9CQ82 UniProt | EBI | MGI Sequence Detail 176 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 30
    cDNA 30

    Microarray probesets 6
Other
Accession IDs
less
MGI:2140468
References
more
  • Summaries
    All 45
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory