Timm22 MGI Mouse Gene Detail - MGI:1929742 - translocase of inner mitochondrial membrane 22

Symbol

Timm22
Name

translocase of inner mitochondrial membrane 22
Synonyms

2610511O07Rik

Feature Type

protein coding gene
IDs

MGI:1929742
NCBI Gene: 56322
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr11:76297778-76307118 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 45.92 cM, cytoband B4
Mapping Data

2 experiments

SNPs within 2kb

277 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929742	protein coding gene	Chr11:76297751-76307139 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018734	protein coding gene	Chr11:77236957-77247346 (+)
A/J	MGP_AJ_G0018700	protein coding gene	Chr11:74352976-74362077 (+)
AKR/J	MGP_AKRJ_G0018670	protein coding gene	Chr11:76611374-76620476 (+)
BALB/cJ	MGP_BALBcJ_G0018674	protein coding gene	Chr11:74735557-74744659 (+)
C3H/HeJ	MGP_C3HHeJ_G0018487	protein coding gene	Chr11:76622062-76631744 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019125	protein coding gene	Chr11:79664350-79677743 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016760	protein coding gene	Chr11:71352472-71362122 (+)
CAST/EiJ	MGP_CASTEiJ_G0018041	protein coding gene	Chr11:77014597-77025730 (+)
CBA/J	MGP_CBAJ_G0018457	protein coding gene	Chr11:83144688-83157133 (+)
DBA/2J	MGP_DBA2J_G0018566	protein coding gene	Chr11:73949300-73958409 (+)
FVB/NJ	MGP_FVBNJ_G0018556	protein coding gene	Chr11:73499650-73508755 (+)
LP/J	MGP_LPJ_G0018637	protein coding gene	Chr11:77813390-77823367 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018582	protein coding gene	Chr11:83639328-83651019 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019165	protein coding gene	Chr11:76798946-76808848 (+)
PWK/PhJ	MGP_PWKPhJ_G0017812	protein coding gene	Chr11:74674171-74684097 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017603	protein coding gene	Chr11:76371939-76380845 (+)
WSB/EiJ	MGP_WSBEiJ_G0018094	protein coding gene	Chr11:76626454-76636136 (+)

Human Ortholog

TIMM22, translocase of inner mitochondrial membrane 22

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TIMM22, translocase of inner mitochondrial membrane 22
Synonyms

COXPD43, TEX4, TIM22
Links

HGNC:17317

NCBI Gene ID: 29928

neXtProt AC: NX_Q9Y584

UniProt: Q9Y584
Chr Location

17p13.3; chr17:997129-1003671 (+) GRCh38

MGI Vertebrate Homology

Timm22 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TIMM22
Gene Tree

Timm22

Diseases

1 with human TIMM22 associations

				Human Disease	Mouse Models
				combined oxidative phosphorylation deficiency 43 IDs combined oxidative phosphorylation deficiency 43 DOID:0112116 OMIM:618851

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

13 phenotypes from 1 allele in 2 genetic backgrounds
1 images
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Targeted

4
Genomic Mutations

2 involving Timm22
Incidental Mutations

CvDC
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete embryonic lethality by E9.5.

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All GO Annotations

13
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

770
Tissues

53
cDNA Data

66
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase timm22

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All Sequences

56
RefSeq

7
UniProt

4
CCDS

CCDS25065.1, CCDS70245.1

Ensembl

ENSMUSG00000020843 (Evidence)
NCBI Gene

56322

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020843	Ensembl Gene Model \| MGI Sequence Detail	9341	C57BL/6J	± kb
transcript	ENSMUST00000021203	Ensembl \| MGI Sequence Detail	2817	Not Applicable
polypeptide	ENSMUSP00000021203	Ensembl \| MGI Sequence Detail	194	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000016346 mitochondrial import inner membrane translocase subunit Tim22

(term hierarchy)
InterPro Domains

IPR039175 Mitochondrial import inner membrane translocase subunit TIM22

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All nucleic 68

cDNA 67

Primer pair 1

Microarray probesets 4

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MGI:1914749

Summaries

All 45

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 17
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Timm22:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103089	Chr11:76297991-76298027 (+)	231 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24