Sar1b MGI Mouse Gene Detail - MGI:1913647 - secretion associated Ras related GTPase 1B

Symbol

Sar1b
Name

secretion associated Ras related GTPase 1B
Synonyms

2310075M17Rik, 2900019I22Rik, Sara2

Feature Type

protein coding gene
IDs

MGI:1913647
NCBI Gene: 66397
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:51654514-51682752 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 31.41 cM
Mapping Data

1 experiment

SNPs within 2kb

720 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913647	protein coding gene	Chr11:51654490-51682780 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018276	protein coding gene	Chr11:51032075-51061541 (+)
A/J	MGP_AJ_G0018245	protein coding gene	Chr11:49102033-49130057 (+)
AKR/J	MGP_AKRJ_G0018215	protein coding gene	Chr11:50644556-50675528 (+)
BALB/cJ	MGP_BALBcJ_G0018216	protein coding gene	Chr11:49401384-49430315 (+)
C3H/HeJ	MGP_C3HHeJ_G0018027	protein coding gene	Chr11:50676788-50705204 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018666	protein coding gene	Chr11:52569689-52598679 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016318	protein coding gene	Chr11:46659274-46686017 (+)
CAST/EiJ	MGP_CASTEiJ_G0017591	protein coding gene	Chr11:50672305-50702595 (+)
CBA/J	MGP_CBAJ_G0018002	protein coding gene	Chr11:55039449-55067632 (+)
DBA/2J	MGP_DBA2J_G0018109	protein coding gene	Chr11:48805166-48834151 (+)
FVB/NJ	MGP_FVBNJ_G0018104	protein coding gene	Chr11:48523535-48554871 (+)
LP/J	MGP_LPJ_G0018185	protein coding gene	Chr11:51444380-51472843 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018127	protein coding gene	Chr11:56443242-56478813 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018709	protein coding gene	Chr11:50747526-50775009 (+)
PWK/PhJ	MGP_PWKPhJ_G0017367	protein coding gene	Chr11:49329650-49357516 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017162	protein coding gene	Chr11:50479111-50510003 (+)
WSB/EiJ	MGP_WSBEiJ_G0017639	protein coding gene	Chr11:50388241-50417391 (+)

Human Ortholog

SAR1B, secretion associated Ras related GTPase 1B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SAR1B, secretion associated Ras related GTPase 1B
Synonyms

ANDD, CMRD, GTBPB, SARA2
Links

HGNC:10535

NCBI Gene ID: 51128

neXtProt AC: NX_Q9Y6B6

UniProt: Q9Y6B6
Chr Location

5q31.1; chr5:134601149-134649271 (-) GRCh38

MGI Vertebrate Homology

Sar1b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SAR1B
Gene Tree

Sar1b

Diseases

1 with Sar1b mouse models; 1 with human SAR1B associations

Human Disease

Mouse Models

chylomicron retention disease

IDs

View 2 models

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

1 with disease annotations

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Phenotype Summary

18 phenotypes from 3 alleles in 4 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

38
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

30
Targeted

5
Genomic Mutations

1 involving Sar1b
Incidental Mutations

APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele show late-gestational lethality. Heterozygous mice exhibit lower triglyceride, total cholesterol, and HDL cholesterol levels, fat malabsorption, and reduced chylomicron secretion.

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All GO Annotations

44
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

729
Tissues

12
cDNA Data

131
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sar1b

ZFIN sar1b

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All Sequences

39
RefSeq

2
UniProt

3
CCDS

CCDS24661.1

Ensembl

ENSMUSG00000020386 (Evidence)
NCBI Gene

66397

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020386	Ensembl Gene Model \| MGI Sequence Detail	28239	C57BL/6J	± kb
transcript	ENSMUST00000020653	Ensembl \| MGI Sequence Detail	1201	Not Applicable
polypeptide	ENSMUSP00000020653	Ensembl \| MGI Sequence Detail	198	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014455 GTP-binding protein SAR1b

(term hierarchy)
EC

3.6.5.2
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR006689 Small GTPase superfamily, ARF/SAR type

IPR006687 Small GTPase superfamily, SAR1-type

IPR005225 Small GTP-binding protein domain
GlyGen

Q9CQC9 1 site, 1 O-linked glycan (1 site)

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All nucleic 131

cDNA 131

Microarray probesets 4

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MGI:1920195

Summaries

All 53

Developmental Gene Expression 2

Diseases 1

Gene Ontology 9

Phenotypes 19
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:349757 Tang VT, et al., Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivo. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2322164121

TSS for Sar1b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101290	Chr11:51654481-51654496 (+)	-25 bp
Tssr101291	Chr11:51654509-51654576 (+)	29 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24