Rnf138 MGI Mouse Gene Detail - MGI:1929211

Symbol

Rnf138
Name

ring finger protein 138
Synonyms

2410015A17Rik, 2810480D20Rik, Trif-d

Feature Type

protein coding gene
IDs

MGI:1929211
NCBI Gene: 56515
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr18:21134398-21161281 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 11.73 cM, cytoband A2
Mapping Data

2 experiments

SNPs within 2kb

593 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929211	protein coding gene	Chr18:21134202-21161281 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024186	protein coding gene	Chr18:18621516-18648866 (+)
A/J	MGP_AJ_G0024150	protein coding gene	Chr18:18127745-18154540 (+)
AKR/J	MGP_AKRJ_G0024119	protein coding gene	Chr18:18684084-18713541 (+)
BALB/cJ	MGP_BALBcJ_G0024150	protein coding gene	Chr18:18187447-18214244 (+)
C3H/HeJ	MGP_C3HHeJ_G0023918	protein coding gene	Chr18:18624002-18656759 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024592	protein coding gene	Chr18:19509196-19541364 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022034	protein coding gene	Chr18:17239775-17267049 (+)
CAST/EiJ	MGP_CASTEiJ_G0023391	protein coding gene	Chr18:18406870-18436779 (+)
CBA/J	MGP_CBAJ_G0023886	protein coding gene	Chr18:19998298-20028907 (+)
DBA/2J	MGP_DBA2J_G0024018	protein coding gene	Chr18:17836396-17863437 (+)
FVB/NJ	MGP_FVBNJ_G0023984	protein coding gene	Chr18:17614687-17641841 (+)
LP/J	MGP_LPJ_G0024099	protein coding gene	Chr18:18777081-18808729 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024012	protein coding gene	Chr18:20892292-20919370 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024640	protein coding gene	Chr18:18445607-18474365 (+)
PWK/PhJ	MGP_PWKPhJ_G0023136	protein coding gene	Chr18:17941157-17968934 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022945	protein coding gene	Chr18:18650605-18677728 (+)
WSB/EiJ	MGP_WSBEiJ_G0023456	protein coding gene	Chr18:18368960-18396378 (+)

Human Ortholog

RNF138, ring finger protein 138

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNF138, ring finger protein 138
Synonyms

hNARF, HSD-4, NARF, STRIN
Links

HGNC:17765

NCBI Gene ID: 51444

neXtProt AC: NX_Q8WVD3

UniProt: Q8WVD3
Chr Location

18q12.1; chr18:32091874-32131561 (+) GRCh38

MGI Vertebrate Homology

Rnf138 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: RNF138
Gene Tree

Rnf138

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

112
Gene trapped

107
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

78 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null males show increased spermatogenic cell apoptosis, loss of proliferative spermatogonia, delayed development of spermatozoa and impaired fertility.

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All GO Annotations

22
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

900
Tissues

54
cDNA Data

60
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rnf138

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All Sequences

64
RefSeq

17
UniProt

3
CCDS

CCDS29089.1, CCDS29090.1

Ensembl

ENSMUSG00000024317 (Evidence)
NCBI Gene

56515

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024317	Ensembl Gene Model \| MGI Sequence Detail	26884	C57BL/6J	± kb
transcript	ENSMUST00000234107	Ensembl \| MGI Sequence Detail	2422	Not Applicable
polypeptide	ENSMUSP00000157102	Ensembl \| MGI Sequence Detail	245	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014084 E3 ubiquitin-protein ligase RNF138

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR008598 Drought induced 19 protein type, zinc-binding domain

IPR052498 E3 ubiquitin-protein ligase RNF138

IPR034734 Zinc finger C2HC RNF-type

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type
GlyGen

Q9CQE0 1 site, 1 O-linked glycan (1 site)

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All nucleic 63

cDNA 63

Microarray probesets 8

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MGI:1914242, MGI:1920059

Summaries

All 48

Developmental Gene Expression 5

Gene Ontology 6

Phenotypes 13
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rnf138:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150216	Chr18:21134303-21134323 (+)	-85 bp
Tssr150217	Chr18:21134324-21134330 (+)	-71 bp
Tssr150218	Chr18:21134333-21134344 (+)	-59 bp
Tssr150219	Chr18:21134349-21134392 (+)	-27 bp
Tssr150220	Chr18:21134410-21134415 (+)	15 bp
Tssr150221	Chr18:21134529-21134548 (+)	141 bp
Tssr150222	Chr18:21134823-21134834 (+)	431 bp
Tssr150223	Chr18:21134835-21134846 (+)	443 bp
Tssr150224	Chr18:21134851-21134867 (+)	461 bp
Tssr150225	Chr18:21134876-21134886 (+)	483 bp
Tssr150226	Chr18:21134934-21135069 (+)	604 bp
Tssr150227	Chr18:21135083-21135092 (+)	690 bp
Tssr5256	Chr18:21159361-21159365 (+)	24,965 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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